Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency

Bonner, J.J., Burt, H., Johnson, T.N. et al. (3 more authors) (2021) Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency. European Journal of Pharmaceutical Sciences, 165. 105913. ISSN 0928-0987

Abstract

Metadata

Authors/Creators:
Copyright, Publisher and Additional Information: © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Physiologically-based pharmacokinetics; PBPK; Hydrocortisone; congenital adrenal hyperplasia; Adrenal insufficiency; Multi-particulate; Modified-release
Dates:
  • Accepted: 13 June 2021
  • Published (online): 17 June 2021
  • Published: 1 October 2021
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
Diurnal Ltd, UKn/a
Depositing User: Symplectic Sheffield
Date Deposited: 21 Oct 2021 07:00
Last Modified: 21 Oct 2021 07:00
Status: Published
Publisher: Elsevier BV
Refereed: Yes
Identification Number: https://doi.org/10.1016/j.ejps.2021.105913

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