Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis

Caseley, EA orcid.org/0000-0001-7591-143X, Muench, SP orcid.org/0000-0001-6869-4414 and Jiang, L-H orcid.org/0000-0001-6398-0411 (2021) Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins: Structure, Function, and Bioinformatics. ISSN 0887-3585

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2021 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Caseley, EA, Muench, SP, Jiang, L-H. Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins. 2021; 1- 6. doi:10.1002/prot.26259, which has been published in final form at [https://doi.org/10.1002/prot.26259]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: molecular docking, P2X7R, patch-clamp recording, site-directed mutagenesis, structural modeling, structure–function relationships
Dates:
  • Accepted: 3 October 2021
  • Published (online): 8 October 2021
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
Funding Information:
FunderGrant number
Wellcome Trust099758/Z/12/Z
Depositing User: Symplectic Publications
Date Deposited: 06 Oct 2021 12:09
Last Modified: 22 Nov 2021 13:59
Status: Published online
Publisher: Wiley
Identification Number: https://doi.org/10.1002/prot.26259

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