Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Abstract

Background

Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities.

Methods

Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported.

Results

Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue.

Conclusion

A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.

Metadata

Item Type:	Article
Authors/Creators:	Andelic, N Røe, C Brunborg, C Zeldovich, M Løvstad, M Løke, D Borgen, IM Voormolen, DC Howe, EI Forslund, MV Dahl, HM von Steinbuechel, N Åkerlund, C Amrein, K Andelic, N Andreassen, L Anke, A Antoni, A Audibert, G Azouvi, P Azzolini, ML Bartels, R Barzó, P Beauvais, R Beer, R Bellander, B-M Belli, A Benali, H Berardino, M Beretta, L Blaabjerg, M Bragge, P Brazinova, A Brinck, V Brooker, J Brorsson, C Buki, A Bullinger, M Cabeleira, M Caccioppola, A Calappi, E Calvi, MR Cameron, P Lozano, GC Carbonara, M Cavallo, S Chevallard, G Chieregato, A Citerio, G Ceyisakar, I Clusmann, H Coburn, M Coles, J Cooper, JD Correia, M Čović, A Curry, N Czeiter, E Czosnyka, M Dahyot-Fizelier, C Dark, P Dawes, H Keyser, V Degos, V Corte, FD Boogert, H Depreitere, B Đilvesi, Đ Dixit, A Donoghue, E Dreier, J Dulière, G-L Ercole, A Esser, P Ezer, E Fabricius, M Feigin, VL Foks, K Frisvold, S Furmanov, A Gagliardo, P Galanaud, D Gantner, D Gao, G George, P Ghuysen, A Giga, L Glocker, B Golubovic, J Gomez, PA Gratz, J Gravesteijn, B Grossi, F Gruen, RL Gupta, D Haagsma, JA Haitsma, I Helbok, R Helseth, E Horton, L Huijben, J Hutchinson, PJ Jacobs, B Jankowski, S Jarrett, M Jiang, J-Y Johnson, F Jones, K Karan, M Kolias, AG Kompanje, E Kondziella, D Koraropoulos, E Koskinen, L-O Kovács, N Kowark, A Lagares, A Lanyon, L Laureys, S Lecky, F Ledoux, D Lefering, R Legrand, V Lejeune, A Levi, L Lightfoot, R Lingsma, H Maas, AIR Castaño-León, AM Maegele, M Majdan, M Manara, A Manley, G Martino, C Maréchal, H Mattern, J McMahon, C Melegh, B Menon, D Menovsky, T Mikolic, A Misset, B Muraleedharan, V Murray, L Negru, A Nelson, D Newcombe, V Nieboer, D Nyirádi, J Olubukola, O Oresic, M Ortolano, F Palotie, A Parizel, PM Payen, J-F Perera, N Perlbarg, V Persona, P Peul, W Piippo-Karjalainen, A Pirinen, M Ples, H Polinder, S Pomposo, I Posti, JP Puybasset, L Radoi, A Ragauskas, A Raj, R Rambadagalla, M Rhodes, J Richardson, S Richter, S Ripatti, S Rocka, S Roe, C Roise, O Rosand, J Rosenfeld, JV Rosenlund, C Rosenthal, G Rossaint, R Rossi, S Rueckert, D Rusnák, M Sahuquillo, J Sakowitz, O Sanchez-Porras, R Sandor, J Schäfer, N Schmidt, S Schoechl, H Schoonman, G Schou, RF Schwendenwein, E Sewalt, C Skandsen, T Smielewski, P Sorinola, A Stamatakis, E Stanworth, S Stevens, R Stewart, W Steyerberg, EW Stocchetti, N Sundström, N Synnot, A Takala, R Tamás, V Tamosuitis, T Taylor, MS Ao, BT Tenovuo, O Theadom, A Thomas, M Tibboel, D Timmers, M Tolias, C Trapani, T Maria Tudora, C Vajkoczy, P Vallance, S Valeinis, E Vámos, Z Jagt, M Steen, G Naalt, J Jeroen, TJMVD Essen, TA Hecke, W Heugten, C Praag, D Vyvere, T RoelWijk, PJ Vargiolu, A Vega, E Velt, K Verheyden, J Vespa, PM Vik, A Vilcinis, R Volovici, V Steinbüchel, N Voormolen, D Vulekovic, P Wang, KKW Wiegers, E Williams, G Wilson, L Winzeck, S Wolf, S Yang, Z Ylén, P Younsi, A Zeiler, FA Zelinkova, V Ziverte, A Zoerle, T
Copyright, Publisher and Additional Information:	© The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Head injury; Post-traumatic fatigue; Longitudinal studies; Neurological disorders
Dates:	Published: January 2021 Published (online): 16 July 2020 Accepted: 23 June 2020
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Funding Information:	Funder Grant number EUROPEAN COMMISSION - FP6/FP7 HEALTH-F2-2013-602150
Depositing User:	Symplectic Sheffield
Date Deposited:	24 Sep 2021 16:26
Last Modified:	24 Sep 2021 16:26
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	10.1007/s00415-020-10022-2
Related URLs:	PubMed URL Erratum/Corrigendum
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:178498

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Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

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