SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

Castelli, L.M., Cutillo, L., Souza, C.D.S. et al. (14 more authors) (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16 (1). 53.

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2021 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Keywords: Amyotrophic lateral sclerosis; C9ORF72-repeat expansions; Pre-clinical models; Transcriptome; Genomewide mechanisms of neuroprotection; SRSF1-dependent RNA nuclear export; Disease-modifying gene expression signature; Voltage-gated potassium ion channel
Dates:
  • Accepted: 16 July 2021
  • Published (online): 10 August 2021
  • Published: 10 August 2021
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
Medical Research CouncilMR/M010864/1; MR/K008943/1
Depositing User: Symplectic Sheffield
Date Deposited: 12 Aug 2021 13:11
Last Modified: 14 Aug 2021 04:40
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/s13024-021-00475-y
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