Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Gatto, N., Dos Santos Souza, C., Shaw, A.C. et al. (12 more authors) (2020) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell. e13281. ISSN 1474-9718

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: ageing; astrocytes; direct reprogramming; in vitro model; neurodegeneration; neuroinflammation; neuron‐astrocyte crosstalk; nuclear abnormalities; nucleocytoplasmic transport; oxidative stress
Dates:
  • Accepted: 31 October 2020
  • Published (online): 13 December 2020
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:
FunderGrant number
BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCILBB/S005277/1
Medical Research Council2114458
Depositing User: Symplectic Sheffield
Date Deposited: 16 Dec 2020 15:33
Last Modified: 16 Dec 2020 16:25
Status: Published online
Publisher: Wiley
Refereed: Yes
Identification Number: https://doi.org/10.1111/acel.13281
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