Barberio, B, Mahadeva, S, Black, CJ et al. (2 more authors) (2020) Systematic review with meta-analysis: global prevalence of uninvestigated dyspepsia according to the Rome criteria. Alimentary Pharmacology & Therapeutics, 52 (5). pp. 762-773. ISSN 0269-2813
Abstract
Background
Prevalence of uninvestigated dyspepsia varies across cross‐sectional surveys. This may be due to differences in definitions used or study methodology, rather than global variability.
Aim
To determine the global prevalence of uninvestigated dyspepsia according to Rome criteria.
Methods
MEDLINE and EMBASE were searched to identify population‐based studies reporting prevalence of uninvestigated dyspepsia in adults (≥18 years old) according to Rome I, II, III or IV criteria. Prevalence of uninvestigated dyspepsia was extracted, according to criteria used to define it. Pooled prevalence, according to study location and certain other characteristics, odds ratios (OR), and 95% confidence intervals (CIs) were calculated.
Results
Of 2133 citations evaluated, 67 studies fulfilled eligibility criteria, representing 98 separate populations, comprising 338 383 subjects. Pooled prevalence ranged from 17.6% (95% CI 9.8%‐27.1%) in studies defining uninvestigated dyspepsia according to Rome I criteria, to 6.9% (95% CI 5.7%‐8.2%) in those using Rome IV criteria. Postprandial distress syndrome was the commonest subtype, occurring in 46.2% of participants using Rome III criteria, and 62.8% with Rome IV. Prevalence of uninvestigated dyspepsia was up to 1.5‐fold higher in women, irrespective of the definition used. There was significant heterogeneity between studies in all our analyses, which persisted even when the same criteria were applied and similar methodology was used.
Conclusions
Even when uniform symptom‐based criteria are used to define the presence of uninvestigated dyspepsia, prevalence varies between countries. This suggests that there are environmental, cultural, ethnic, dietary or genetic influences determining symptoms.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Barberio, B, Mahadeva, S, Black, CJ et al. (2 more authors) (2020) Systematic review with meta-analysis: global prevalence of uninvestigated dyspepsia according to the Rome criteria. Alimentary Pharmacology & Therapeutics, 52 (5). pp. 762-773. ISSN 0269-2813, which has been published in final form at https://doi.org/10.1111/apt.16006. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Sep 2020 13:45 |
Last Modified: | 28 Jul 2021 00:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/apt.16006 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165990 |