Minter, A., Hoschler, K., Jagne, Y.J. et al. (7 more authors) (2022) Estimation of seasonal influenza attack rates and antibody dynamics in children using cross-sectional serological data. The Journal of Infectious Diseases, 225 (10). pp. 1750-1754. ISSN 0022-1899
Abstract
Directly measuring evidence of influenza infections is difficult, especially in low surveillance settings such as sub-Saharan Africa. Using a Bayesian model, we estimated unobserved infection times and underlying antibody responses to influenza A/H3N2 using cross-sectional serum antibody responses to four strains in children aged 24-60 months. Among the 242 individuals, we estimated a variable seasonal attack rate and found that most children had at least one infection before two years of age. Our results are consistent with previously published high attack rates in children. The modelling approach highlights how cross-sectional serological data can be used to estimate epidemiological dynamics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Influenza; childhood infection; The Gambia; serology; Bayesian model |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 Jul 2020 07:16 |
Last Modified: | 24 May 2022 09:16 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Refereed: | Yes |
Identification Number: | 10.1093/infdis/jiaa338 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:162684 |