Complement peptide receptors (version 2019.4) in the IUPHAR/BPS guide to pharmacology database

Abstract

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [98]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.

Metadata

Authors/Creators:	Cianciulli, A. Coulthard, L. Hawksworth, O. Lee, J.D. Mitolo, V. Monk, P. https://orcid.org/0000-0003-4637-3059 Panaro, M.A. Woodruff, T.M.
Copyright, Publisher and Additional Information:	© 2019 The Author(s).
Dates:	Published (online): 16 September 2019 Published: 16 September 2019
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	04 Dec 2019 10:44
Last Modified:	04 Dec 2019 10:44
Status:	Published
Publisher:	Edinburgh University Library
Refereed:	Yes
Identification Number:	https://doi.org/10.2218/gtopdb/f5/2019.4

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Complement peptide receptors (version 2019.4) in the IUPHAR/BPS guide to pharmacology database

Abstract

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