Hughes, P.J.C., Smith, L. orcid.org/0000-0002-5769-423X, Chan, H.-F. orcid.org/0000-0002-5382-2097 et al. (6 more authors) (2019) Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers. Journal of Applied Physiology, 126 (1). pp. 183-192. ISSN 8750-7587
Abstract
In this study, the effect of lung volume on quantitative measures of lung ventilation was investigated using MRI with hyperpolarized 3He and 129Xe. Six volunteers were imaged with hyperpolarized 3He at five different lung volumes (residual volume (RV), RV+1L, functional residual capacity (FRC), FRC+1L and total lung capacity (TLC)), and three were also imaged with hyperpolarized 129Xe. Imaging at each of the lung volumes was repeated twice on the same day with corresponding 1H lung anatomical images. Percentage lung ventilated volume (%VV) and variation of signal intensity (heterogeneity score, Hscore) were evaluated. Increased ventilation heterogeneity, quantified by reduced %VV and increased Hscore, was observed at lower lung volumes with the least ventilation heterogeneity observed at TLC. For 3He MRI data, the coefficient of variation of %VV was less than 1.5% and less than 5.5% for Hscore at all lung volumes, whilst for 129Xe data the values were 4% and 10% respectively. Generally, %VV generated from 129Xe images was lower than that seen from 3He images. The good repeatability of 3He %VV found here supports prior publications showing that percentage lung ventilated volume is a robust method for assessing global lung ventilation. The greater ventilation heterogeneity observed at lower lung volumes indicates that there may be partial airway closure in healthy lungs and that lung volume should be carefully considered for reliable longitudinal measurements of %VV and Hscore. The results suggest that imaging patients at different lung volumes may help to elucidate obstructive disease pathophysiology and progression.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 American Physiological Society. This is an author produced version of a paper subsequently published in Journal of Applied Physiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Hyperpolarized gas; Imaging; Inflation; Lungs; Magnetic Resonance Imaging |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number NATIONAL INSTITUTE FOR HEALTH RESEARCH ICA-CDRF-2015-01-027 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Jan 2019 13:01 |
Last Modified: | 26 Oct 2021 14:08 |
Status: | Published |
Publisher: | American Physiological Society |
Refereed: | Yes |
Identification Number: | 10.1152/japplphysiol.00464.2018 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138805 |