Lesbirel, S. and Wilson, S.A. orcid.org/0000-0003-3073-258X (2018) The m6A‑methylase complex and mRNA export. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.
Abstract
During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N6‑methyladenosine (m6A) modification. In this review we discuss the recent evidence of coupling between the m6A modification, RNA processing and export.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Oct 2018 12:28 |
Last Modified: | 22 Oct 2018 12:28 |
Published Version: | https://doi.org/10.1016/j.bbagrm.2018.09.008 |
Status: | Published online |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.bbagrm.2018.09.008 |
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