Moura, I, Monot, M, Tani, C et al. (6 more authors) (2014) Multidisciplinary Analysis of a Nontoxigenic Clostridium difficile Strain with Stable Resistance to Metronidazole. Antimicrobial Agents and Chemotherapy, 58 (8). pp. 4957-4960. ISSN 0066-4804
Abstract
Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.
Metadata
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| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 31 Jul 2018 10:51 |
| Last Modified: | 31 Jul 2018 10:51 |
| Status: | Published |
| Publisher: | American Society for Microbiology |
| Identification Number: | https://doi.org/10.1128/AAC.02350-14 |
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