Rode, B, Bailey, MA orcid.org/0000-0001-5038-1970, Marthan, R et al. (2 more authors) (2018) ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension. Physiology, 33 (4). pp. 261-268. ISSN 1548-9213
Abstract
Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2+ channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.
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Copyright, Publisher and Additional Information: | © 2018 American Physiological Society. This is an author produced version of a paper published in Physiology. Uploaded in accordance with the publisher's self-archiving policy. | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 18 Jul 2018 16:16 | ||||
Last Modified: | 13 Jun 2019 00:41 | ||||
Status: | Published | ||||
Publisher: | American Physiological Society | ||||
Identification Number: | https://doi.org/10.1152/physiol.00016.2018 | ||||
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