Schotten, C, Howard, JL, Jenkins, RL et al. (2 more authors) (2018) A continuous flow-batch hybrid reactor for commodity chemical synthesis enabled by inline NMR and temperature monitoring. Tetrahedron, 74 (38). pp. 5503-5509. ISSN 0040-4020
Abstract
Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF2H after 105 min.
Metadata
| Authors/Creators: |
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| Keywords: | Continuous flow, Flow NMRI, nline monitoring, Exotherm control, Space time yield |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 19 Jun 2018 15:04 |
| Last Modified: | 17 Sep 2018 13:45 |
| Status: | Published |
| Publisher: | Elsevier |
| Identification Number: | https://doi.org/10.1016/j.tet.2018.05.070 |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)