Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs the cardiac action potential duration

Cheng, L, Al-Owais, MM, Covarrubias, M et al. (4 more authors) (2018) Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs the cardiac action potential duration. Journal of Biological Chemistry, 293 (28). pp. 11022-11032. ISSN 0021-9258

Abstract

Metadata

Authors/Creators:
Copyright, Publisher and Additional Information: This research was originally published in the Journal of Biological Chemistry. Lan Cheng, Moza M. Al-Owais, Manuel Covarrubias, Walter J. Koch, David R. Manning, Chris Peers, and Natalia Riobo-Del Galdo. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs the cardiac action potential duration. J. Biol. Chem. 2018, Vol 293 (28), pp 11022-11032. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Smoothened; Hedgehog; G proteins; Kv channels; arrhythmias; action potential
Dates:
  • Published: 13 July 2018
  • Accepted: 25 May 2018
  • Published (online): 25 May 2018
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
Funding Information:
FunderGrant number
National Institute of Health - NIH (PHS)562836/10041422/17219
Depositing User: Symplectic Publications
Date Deposited: 04 Jun 2018 11:27
Last Modified: 01 Jul 2019 11:24
Status: Published
Publisher: American Society for Biochemistry and Molecular Biology
Identification Number: https://doi.org/10.1074/jbc.RA118.001989

Share / Export

Statistics