Sciola, M.I., Morris, P.D., Gosling, R. et al. (3 more authors) (2018) The Impact of Objective Mathematical Analysis During Fractional Flow Reserve Measurement. Results from the OMA-FFR Study. EuroIntervention, 14 (8). pp. 935-941. ISSN 1774-024X
Abstract
AIMS: Fractional flow reserve (FFR), the reference-standard for guiding coronary revascularisation, is most commonly acquired during intravenous adenosine infusion. Results may be sensitive to system- and operator-dependent variability in how pressure data are analysed and interpreted. We developed a computational protocol to process the recorded pressure signals in a consistent manner to objectively quantify FFR. We studied the impact upon lesion (re)classification and compared this with the operator-selected FFR obtained during cardiac catheterisation. METHODS AND RESULTS: The algorithm used a moving average and Fourier transformation to identify the Pd/Pa ratio at its nadir (FFRmin) and during the stable hyperaemic period (FFRstable) in <2s with 100% repeatability, in 163 coronary stenoses (93 patients). The mean operator-selected FFR (FFRCL) was higher than FFRmin and lower than FFRstable (0.779 vs 0.762 vs 0.806, P=<0.01). Compared with FFRmin, FFRstable resulted in 16.5% of all lesions being re-classified, all from significant to non-significant (p<0.01). FFRCL classified lesion significance differently to both FFRstable and FFRmin (11.7% and 6.1% lesions reclassified respectively, p<0.01). CONCLUSIONS: Subtle differences in how pressure data are analysed and interpreted by the operator during adenosine infusion result in significant differences in the classification of physiological lesion significance. An algorithmic analysis may be helpful in standardising FFR analysis providing an objective and repeatable result.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Europa Digital and Publishing |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number SHEFFIELD HOSPITALS CHARITABLE TRUST 121341/5 WELLCOME TRUST (THE) HICF-R6-365 BRITISH HEART FOUNDATION FS/12/85/29869 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 May 2018 15:31 |
Last Modified: | 02 Dec 2020 09:05 |
Status: | Published |
Publisher: | Europa Digital Publishing |
Refereed: | Yes |
Identification Number: | 10.4244/EIJ-D-17-00826 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:130795 |