Vijayakrishnan, Jayaram, Studd, James, Broderick, Peter et al. (47 more authors) (2018) Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. Nature Communications. 1340. ISSN 2041-1723
Abstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Metadata
Authors/Creators: |
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Keywords: | Child, Child, Preschool, Core Binding Factor Alpha 2 Subunit/genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glycosyltransferases/genetics, HLA Antigens/genetics, Humans, Male, Oncogene Proteins, Fusion/genetics, Polymorphism, Single Nucleotide, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics, Prognosis, Risk Factors |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 19 Apr 2018 13:30 |
Last Modified: | 07 Dec 2022 12:33 |
Published Version: | https://doi.org/10.1038/s41467-018-03178-z |
Status: | Published |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1038/s41467-018-03178-z |
Related URLs: |
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Description: Genome wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia