Adaptive designs in clinical trials: why use them, and how to run and report them

Pallmann, P., Bedding, A.W., Choodari-Oskooei, B. et al. (13 more authors) (2018) Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine, 16 (29). ISSN 1741-7015



  • Pallmann, P.
  • Bedding, A.W.
  • Choodari-Oskooei, B.
  • Flight, L. ORCID logo
  • Dimairo, M.
  • Hampson, L.V.
  • Holmes, J.
  • Mander, A.P.
  • Odondi, L.
  • Sydes, M.R.
  • Villar, S.S.
  • Wason, J.M.S.
  • Weir, C.J.
  • Wheeler, G.M.
  • Yap, C.
  • Jaki, T.
Copyright, Publisher and Additional Information: © The Author(s). 2018Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0International License (, which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to theCreative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver( applies to the data made available in this article, unless otherwise stated.
Keywords: Statistical methods; Adaptive design; Flexible design; Interim analysis; Design modification; Seamless design
  • Published: 28 February 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research
Funding Information:
FunderGrant number
Depositing User: Symplectic Sheffield
Date Deposited: 02 Mar 2018 11:25
Last Modified: 02 Mar 2018 11:25
Published Version:
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: