Ho, Hon Eong orcid.org/0000-0003-1037-2505, James, Michael J orcid.org/0000-0003-2591-0046, O'Brien, Peter orcid.org/0000-0002-9966-1962 et al. (2 more authors) (2018) Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones : Total Synthesis of Indolizidine 209D. Organic Letters. pp. 1439-1443. ISSN 1523-7052
Abstract
An efficient Ag(I)-catalyzed π-acid activation method for the cyclization of cyclic ketimine-tethered ynones is reported. Various nitrogen-containing scaffolds commonly found in bioactive alkaloids can be prepared in high yields, and the utility of the method is demonstrated by a formal synthesis of (±)-lasubine II and in a short total synthesis of (±)-indolizidine 209D.
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Copyright, Publisher and Additional Information: | © 2018 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details | ||||
Keywords: | Journal Article | ||||
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 12 Feb 2018 16:40 | ||||
Last Modified: | 18 Mar 2023 00:14 | ||||
Published Version: | https://doi.org/10.1021/acs.orglett.8b00225 | ||||
Status: | Published online | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1021/acs.orglett.8b00225 |
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