Stevers, LM, Sijbesma, E, Botta, M et al. (13 more authors) (2017) Modulators of 14-3-3 Protein-Protein Interactions. Journal of Medicinal Chemistry. ISSN 0022-2623
Abstract
Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of protein-protein interactions (PPIs) has now been widely recognized as an attractive means to therapeutically intervene in disease states. Even though this is a challenging endeavor and PPIs have long been regarded as 'undruggable' targets, the last two decades have seen an increasing number of successful examples of PPI modulators resulting in a growing interest in this field. PPI modulation requires novel approaches and the integrated efforts of multiple disciplines to be a fruitful strategy. This Perspective focuses on the hub protein 14-3-3, which has several hundred identified protein interaction partners and is therefore involved in a wide range of cellular processes and diseases. Here, we aim to provide an integrated overview of the approaches explored for the modulation of 14-3-3 PPIs and review the examples resulting from these efforts in both inhibiting and stabilizing specific 14-3-3 protein complexes by small molecules, peptide-mimetics and natural products.
Metadata
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Copyright, Publisher and Additional Information: | © 2017 American Chemical Society. This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 01 Nov 2017 16:40 | ||||
Last Modified: | 01 Nov 2017 16:40 | ||||
Status: | Published | ||||
Publisher: | American Chemical Society | ||||
Identification Number: | https://doi.org/10.1021/acs.jmedchem.7b00574 |