Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

Liu, F. orcid.org/0000-0002-2917-7323, Walters, S.J. orcid.org/0000-0001-9000-8126 and Julious, S.A. (2017) Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity. BMC Medical Research Methodology, 17 (1). 149.

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Copyright, Publisher and Additional Information: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Emax; NDLM; Dose response; Bayesian; Rheumatoid arthritis
Dates:
  • Accepted: 31 August 2017
  • Published (online): 2 October 2017
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Sheffield Centre for Health and Related Research
Depositing User: Symplectic Sheffield
Date Deposited: 09 Oct 2017 14:55
Last Modified: 09 Oct 2017 15:09
Published Version: https://doi.org/10.1186/s12874-017-0416-3
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/s12874-017-0416-3
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