A cellular based model of the colon crypt suggests novel effects forApc phenotype in colorectal carcinogenesis
Ingham Dempster, T., Corfe, B.M. and Walker, D.C.
(2018)
A cellular based model of the colon crypt suggests novel effects forApc phenotype in colorectal carcinogenesis.
Journal of Computational Science, 24.
pp. 125-131.
ISSN 1877-7503
Abstract
Colorectal cancer (CRC) is a major cause of cancer mortality; loss of the Apc gene is an early step in the formation of CRC.
A new computational model of the colonic crypt has been developed to simulate the effects of Apc loss. The model includes a region of flat mucosa, which has not previously been considered in the context of Apc loss.
The model suggests that Apc loss confers a survival advantage at the crypt mouth which may be a previously unknown method of mutation fixation.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)