Ingham Dempster, T., Corfe, B.M. and Walker, D.C. (2017) A cellular based model of the colon crypt suggests novel effects forApc phenotype in colorectal carcinogenesis. Journal of Computational Science. ISSN 1877-7503
Abstract
Colorectal cancer (CRC) is a major cause of cancer mortality; loss of the Apc gene is an early step in the formation of CRC.
A new computational model of the colonic crypt has been developed to simulate the effects of Apc loss. The model includes a region of flat mucosa, which has not previously been considered in the context of Apc loss.
The model suggests that Apc loss confers a survival advantage at the crypt mouth which may be a previously unknown method of mutation fixation.
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Journal of Computational Science. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Agent based modelling; Colon crypt; Apc loss |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Jul 2017 14:05 |
Last Modified: | 22 Jun 2018 00:38 |
Published Version: | https://doi.org/10.1016/j.jocs.2017.06.013 |
Status: | Published online |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.jocs.2017.06.013 |
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