Johnston, J.R., Basatvat, S., Ilyas, Z. et al. (2 more authors)
(2015)
Tribbles in inflammation.
Biochemical Society Transactions, 43.
pp. 1069-1074.
ISSN 0300-5127
Abstract
Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury.
However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase
proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogenactivated
protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our
current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and
in disease development.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)