Imine reductases (IREDs)

Abstract

Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.

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Authors/Creators:	Mangas-Sanchez, Juan France, Scott P Montgomery, Sarah L Aleku, Godwin A Man, Henry Sharma, Mahima https://orcid.org/0000-0003-3960-2212 Ramsden, Jeremy I Grogan, Gideon https://orcid.org/0000-0003-1383-7056 Turner, Nicholas J
Copyright, Publisher and Additional Information:	© 2016 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Dates:	Accepted: 25 November 2016 Published (online): 27 December 2016 Published: April 2017
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Chemistry (York)
Depositing User:	Pure (York)
Date Deposited:	09 Jan 2017 15:48
Last Modified:	06 Dec 2023 11:37
Published Version:	https://doi.org/10.1016/j.cbpa.2016.11.022
Status:	Published
Refereed:	Yes
Identification Number:	https://doi.org/10.1016/j.cbpa.2016.11.022

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Imine reductases (IREDs)

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