Masumoto, J., Yang, K., Varambally, S. et al. (12 more authors) (2006) Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. Journal of Experimental Medicine, 203 (1). pp. 203-213. ISSN 0022-1007
Abstract
Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by Nod1, synthetic ligand compounds possessing enhanced ability to stimulate Nod1 were developed to study the function of Nod1. Stimulation of epithelial cells with Nod1 stimulatory molecules induced chemokines and other proinl ammatory molecules that are important for innate immune responses and recruitment of acute inl ammatory cells. Administration of Nod1 ligands into mice induced chemokines and recruitment of acute inl ammatory cells, an activity that was abolished in Nod1-null mice. Microarray analysis revealed that Nod1 stimulation induces a restricted number of genes in intestinal epithelial cells compared with that induced by tumor necrosis factor (TNF) α. Nod1 stimulation did not induce TNFα, interleukin 12, and interferon γ, suggesting that the primary role of Nod1 is to induce the recruitment of immune cells. These results indicate that Nod1 functions as a pathogen recognition molecule to induce expression of molecules involved in the early stages of the innate immune response.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2006 Rockefeller University Press. Made available under the Creative Commons Attribution-Noncommercial-ShareAlike 4.0 International License (CC-BY-NC-SA) with open access after six months. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Jan 2017 10:32 |
Last Modified: | 06 Jan 2017 10:32 |
Published Version: | https://doi.org/10.1084/jem.20051229 |
Status: | Published |
Publisher: | Rockefeller University Press |
Refereed: | Yes |
Identification Number: | 10.1084/jem.20051229 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108121 |
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