A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II
Matthews, F.E., Stephan, B.C.M., Robinson, L. et al. (22 more authors)
(2016)
A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II.
Nature Communications, 7.
11398.
p. 11398.
ISSN 2041-1723
Abstract
Dramatic global increases in future numbers of people with dementia have been predicted.
No multicentre population-based study powered to detect changes over time has reported
dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) undertook baseline
interviews in populations aged 65 þ years in England and Wales (1989–1994). Three areas
(CFAS I) were selected for new sampling two decades later (2008–2011) with same
geographical boundaries, sampling and approach methods (CFAS II). At 2 years CFAS I
interviewed 5,156 (76% response) with 5,288 interviewed in CFAS II (74% response). Here
we report a 20% drop in incidence (95% CI: 0–40%), driven by a reduction in men across all
ages above 65. In the UK we estimate 209,600 new dementia cases per year. This study was
uniquely designed to test for differences across geography and time. A reduction of
age-specific incidence means that the numbers of people estimated to develop dementia in
any year has remained relatively stable.
Metadata
Authors/Creators:
Matthews, F.E.
Stephan, B.C.M.
Robinson, L.
Jagger, C.
Barnes, L.E.
Arthur, A.
Brayne, C.
Comas-Herrera, A.
Wittenberg, R.
Dening, T.
McCracken, C.F.M.
Moody, C.
Parry, B.
Green, E.
Barnes, R.
Warwick, J.
Gao, L.
Mattison, A.
Baldwin, C.
Harrison, S.
Woods, B.
McKeith, I.G.
Ince, P.G.
Wharton, S.B.
Forster, G.
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