Items where authors include "Jiang, L-H"

Article

Malko, P orcid.org/0000-0002-5464-806X, Jia, X, Wood, I orcid.org/0000-0003-1886-2533 et al. (1 more author) (2023) Piezo1 channel-mediated Ca2+ signalling inhibits LPS-induced activation of the NF-κB inflammatory signalling pathway and generation of TNF-α and IL-6 in microglial cells. Glia, 71 (4). pp. 848-865. ISSN 0894-1491

Yin, Y-L, Wang, H-H, Gui, Z-C et al. (15 more authors) (2022) Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus. Antioxidants, 11 (11). 2241. p. 2241. ISSN 2076-3921

Man, K, Joukhdar, H, Manz, XD et al. (4 more authors) (2022) Bone tissue engineering using 3D silk scaffolds and human dental pulp stromal cells epigenetic reprogrammed with the selective histone deacetylase inhibitor MI192. Cell and Tissue Research, 388 (3). pp. 565-581. ISSN 0302-766X

Jia, X, Gao, C, Wang, X et al. (2 more authors) (2022) Differential regulation by mechanical stretch of the expressions of large-conductance Ca2+-activated K+ channel and L-type voltage-dependent Ca2+ channel in rat uterine smooth muscle cells. Journal of Membrane Biology, 255 (2-3). pp. 357-361. ISSN 0022-2631

Caseley, EA orcid.org/0000-0001-7591-143X, Muench, SP orcid.org/0000-0001-6869-4414 and Jiang, L-H orcid.org/0000-0001-6398-0411 (2022) Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis. Proteins: Structure, Function, and Bioinformatics, 90 (3). pp. 619-624. ISSN 0887-3585

Wang, L, Roger, S, Yang, XB orcid.org/0000-0002-0144-2826 et al. (1 more author) (2021) Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions. Frontiers in Bioscience - Landmark, 26 (12). pp. 1737-1745. ISSN 1093-9946

Qiu, Y, Xue, X-J, Liu, G et al. (13 more authors) (2021) Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway. Chinese Medicine, 16 (1). 136. ISSN 1749-8546

Man, K, Mekhileri, NV, Lim, KS et al. (3 more authors) (2021) MI192 induced epigenetic reprogramming enhances the therapeutic efficacy of human bone marrows stromal cells for bone regeneration. Bone, 153. 116138. ISSN 8756-3282

Yu, X, Xie, Y, Zhang, X et al. (15 more authors) (2021) Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Reports, 37 (7). 110025. ISSN 2211-1247

Jiang, L-H orcid.org/0000-0001-6398-0411, Caseley, EA orcid.org/0000-0001-7591-143X, Muench, SP orcid.org/0000-0001-6869-4414 et al. (1 more author) (2021) Structural basis for the functional properties of the P2X7 receptor for extracellular ATP. Purinergic Signalling, 17 (3). pp. 331-344. ISSN 1573-9538

Hu, X, Wu, L, Liu, X et al. (9 more authors) (2021) Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy. Oxidative Medicine and Cellular Longevity, 2021. 7356266. ISSN 1942-0900

Jiang, L-H orcid.org/0000-0001-6398-0411, ÇİĞ, B and Derouiche, S (2021) Editorial: Emerging Roles of TRP Channels in Brain Pathology. Frontiers in Cell and Developmental Biology. ISSN 2296-634X

Jiang, L-H orcid.org/0000-0001-6398-0411, Adinolfi, E and Roger, S (2021) Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics. Frontiers in Pharmacology, 12. 711593. ISSN 1663-9812

Ding, R, Yin, Y and Jiang, L-H orcid.org/0000-0001-6398-0411 (2021) Reactive Oxygen Species-Induced TRPM2-Mediated Ca2+ Signalling in Endothelial Cell Function. Antioxidants, 10 (5). 718. ISSN 2076-3921

Liu, L, Zhang, Q, Xiao, S et al. (9 more authors) (2021) Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway. Frontiers in Pharmacology, 12. 606245. ISSN 1663-9812

Sha’fie, MSA, Rathakrishnan, S, Hazanol, IN et al. (7 more authors) (2020) Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway. Antioxidants, 9 (12). 1253. ISSN 2076-3921

Caseley, EA, Muench, SP orcid.org/0000-0001-6869-4414 and Jiang, L-H orcid.org/0000-0001-6398-0411 (2020) Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors. Purinergic Signalling, 16 (4). pp. 485-490. ISSN 1573-9538

Wang, M, Li, J, Dong, S et al. (9 more authors) (2020) Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Particle and Fibre Toxicology, 17. 23. ISSN 1743-8977

Malko, P orcid.org/0000-0002-5464-806X and Jiang, L-H orcid.org/0000-0001-6398-0411 (2020) TRPM2 channel-mediated cell death: an important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions. Redox Biology, 37. 101755. ISSN 2213-2317

Brisson, L, Chadet, S, Lopez-Charcas, O et al. (12 more authors) (2020) P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment. Cancers, 12 (9). 2342. ISSN 2072-6694

Mousawi, F orcid.org/0000-0003-2267-2652, Peng, H, Li, J et al. (5 more authors) (2020) Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling. Stem Cells, 38 (3). pp. 410-421. ISSN 1066-5099

Jia, X, Su, H, Chen, X et al. (8 more authors) (2020) A critical role of the KCa3.1 channel in mechanical stretch‐induced proliferation of rat bone marrow‐derived mesenchymal stem cells. Journal of Cellular and Molecular Medicine, 24 (6). pp. 3739-3744. ISSN 1582-1838

Wang, L, Wei, L, Ding, R et al. (9 more authors) (2020) Predisposition to Alzheimer’s and age-related brain pathologies by PM2.5 exposure: perspective on the roles of oxidative stress and TRPM2 channel. Frontiers in Physiology, 11. 155. ISSN 1664-042X

Mai, C, Mankoo, H, Wei, L et al. (4 more authors) (2020) TRPM2 channel: A novel target for alleviating ischaemia‐reperfusion, chronic cerebral hypo‐perfusion and neonatal hypoxic‐ischaemic brain damage. Journal of Cellular and Molecular Medicine, 24 (1). pp. 4-12. ISSN 1582-1838

Jiang, L-H orcid.org/0000-0001-6398-0411 and Roger, S (2020) Targeting the P2X7 receptor in microglial cells to prevent brain inflammation. Neural Regeneration Research, 15 (7). pp. 1245-1246. ISSN 1673-5374

Milligan, CJ and Jiang, L-H orcid.org/0000-0001-6398-0411 (2019) Automated Planar Patch-Clamp Recording of P2X Receptors. Methods in Molecular Biology, 2041. pp. 285-300. ISSN 1064-3745

Yu, P, Liu, Z, Yu, X et al. (14 more authors) (2019) Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket. Cell Reports, 27 (12). 3684-3695.e4. ISSN 2211-1247

Malko, P, Mortadza, SAS, McWilliam, J et al. (1 more author) (2019) TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies. Frontiers in Pharmacology, 10. ARTN 239. ISSN 1663-9812

An, X, Fu, Z, Mai, C et al. (5 more authors) (2019) Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death. Cells, 8 (1). ARTN 28. ISSN 2073-4409

Jiang, L-H orcid.org/0000-0001-6398-0411, Li, X, Syed Mortadza, SA et al. (2 more authors) (2018) The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia. Ageing Research Reviews, 47. pp. 67-79. ISSN 1568-1637

Wei, L, Syed Mortadza, SA and Jiang, L-H orcid.org/0000-0001-6398-0411 (2018) Melastatin-related transient receptor potential 2 channel in Aβ42-induced neuroinflammation: implications to Alzheimer's disease mechanism and development of therapeutics. Neural regeneration research, 13 (3). pp. 419-420. ISSN 1673-5374

Mortadza, SAS, Sim, JA, Neubrand, VE et al. (1 more author) (2018) A critical role of TRPM2 channel in Aβ₄₂‐induced microglial activation and generation of tumor necrosis factor‐α. Glia, 66 (3). pp. 562-575. ISSN 0894-1491

Jiang, Q, Gao, Y, Wang, C et al. (11 more authors) (2017) Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury. Antioxid Redox Signal, 27 (16). pp. 1297-1316. ISSN 1523-0864

Li, X, Yang, W and Jiang, L-H orcid.org/0000-0001-6398-0411 (2017) Alteration in intracellular Zn2+ homeostasis as a result of TRPM2 channel activation contributes to ROS-induced hippocampal neuronal death. Frontiers in Molecular Neuroscience, 10. 414. ISSN 1662-5099

Jiang, L-H orcid.org/0000-0001-6398-0411, Mousawi, F, Yang, X orcid.org/0000-0002-0144-2826 et al. (1 more author) (2017) ATP-induced Ca2+-signalling mechanisms in the regulation of mesenchymal stem cell migration. Cellular and Molecular Life Sciences, 74 (20). pp. 3697-3710. ISSN 1420-682X

Abuarab, N, Munsey, TS, Jiang, L-H orcid.org/0000-0001-6398-0411 et al. (2 more authors) (2017) High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission. Science Signaling, 10 (490). eaal4161. ISSN 1945-0877

Man, K, Jiang, L-H orcid.org/0000-0001-6398-0411, Foster, R et al. (1 more author) (2017) Immunological Responses to Total Hip Arthroplasty. Journal of Functional Biomaterials, 8 (3). 33. ISSN 2079-4983

Barniol-Xicota, M, Kwak, S-H, Lee, S-D et al. (5 more authors) (2017) Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorganic & Medicinal Chemistry Letters, 27 (4). pp. 759-763. ISSN 0960-894X

Yu, P, Xue, X, Zhang, J et al. (8 more authors) (2017) Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2. The Journal of General Physiology, 149 (2). pp. 219-235. ISSN 0022-1295

Peng, H, Hao, Y, Mousawi, F orcid.org/0000-0003-2267-2652 et al. (6 more authors) (2016) Purinergic and Store‐Operated Ca²⁺ Signaling Mechanisms in Mesenchymal Stem Cells and Their Roles in ATP‐Induced Stimulation of Cell Migration. Stem Cells, 34 (8). pp. 2102-2114. ISSN 1066-5099

Xu, F, Wu, X, Jiang, L-H orcid.org/0000-0001-6398-0411 et al. (2 more authors) (2016) An organelle K⁺ channel is required for osmoregulation in Chlamydomonas reinhardtii. Journal of Cell Science, 129 (15). pp. 3008-3014. ISSN 0021-9533

Wei, L, Caseley, E, Li, D et al. (1 more author) (2016) ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know? Frontiers in Pharmacology, 7. ARTN 5. ISSN 1663-9812

Roger, S, Jelassi, B, Couillin, I et al. (3 more authors) (2015) Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives. BBA: Biomembranes, 1848 (10, Pa). 2584 - 2602. ISSN 0005-2736

Caseley, EA, Muench, SP, Baldwin, SA et al. (3 more authors) (2015) Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human. Bioorganic and Medicinal Chemistry Letters, 25 (16). 3164 - 3167. ISSN 0960-894X

Ye, M, Yang, W, Ainscough, JF et al. (11 more authors) (2014) TRPM2 channel deficiency prevents delayed cytosolic Zn²⁺ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death and Disease, 5. e1541. ISSN 2041-4889

Yu, W, Jiang, L-H, Zheng, Y et al. (3 more authors) (2014) Inactivation of TRPM2 channels by extracellular divalent copper. PLoS ONE, 9 (11). e112071. ISSN 1932-6203

Zhang, Q-Y, Zhang, Y-Y, Xie, J et al. (8 more authors) (2014) Stiff substrates enhance cultured neuronal network activity. Scientific Reports, 4. 6215. ISSN 2045-2322

Caseley, EA, Muench, SP, Roger, S et al. (3 more authors) (2014) Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: Association with diseases, impact on receptor functions and potential use as diagnosis biomarkers. International Journal of Molecular Sciences, 15 (8). 13344 - 13371. ISSN 1661-6596

Zou, J, Ainscough, JF, Yang, W et al. (6 more authors) (2013) A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2. American Journal of Physiology: Cell Physiology, 305 (1). C61 - C69. ISSN 0363-6143

Jelassi, B, Anchelin, M, Chamouton, J et al. (6 more authors) (2013) Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. Carcinogenesis, 34 (7). 1487 - 1496. ISSN 1460-2180

Book Section

Jiang, L-H orcid.org/0000-0001-6398-0411 and Roger, S (2019) Heterologous Expression and Patch-Clamp Recording of P2X Receptors in HEK293 Cells. In: Pelegrín, P, (ed.) Methods in Molecular Biology. Methods in Molecular Biology, 2041 . Springer , New York , pp. 261-273. ISBN 978-1-4939-9716-9