Items where authors include "Iles, MM"

Article

Fuller, H, Iles, MM, Moore, JB et al. (1 more author) (2023) Metabolic Drivers of Dysglycemia in Pregnancy: Ethnic-Specific GWAS of 146 Metabolites and 1-Sample Mendelian Randomisation Analyses in a UK Multi-Ethnic Birth Cohort. Frontiers in Endocrinology, 14. 1157416. ISSN 1664-2392

Haycock, PC, Borges, MC, Burrows, K et al. (32 more authors) (2023) The association between genetically elevated polyunsaturated fatty acids and risk of cancer. eBioMedicine, 91. 104510. ISSN 2352-3964

Sugier, P-E, Lucotte, EA, Domenighetti, C et al. (91 more authors) (2023) Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers. Movement Disorders, 38 (4). pp. 604-615. ISSN 0885-3185

Simonin-Wilmer, I, Ossio, R, Leddin, EM et al. (14 more authors) (2022) Population-based analysis of POT1 variants in a cutaneous melanoma case–control cohort. Journal of Medical Genetics (JMG). ISSN 0022-2593

Long, E, Yin, J, Funderburk, KM et al. (20 more authors) (2022) Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity. American Journal of Human Genetics, 109 (12). pp. 2210-2229. ISSN 0002-9297

Taylor, JC orcid.org/0000-0002-2518-5799, Iversen, LH, Burke, D orcid.org/0000-0002-4342-7464 et al. (5 more authors) (2022) Differences in the management of patients requiring an emergency resection for colonic cancer in two European populations. BJS Open, 6 (5). zrac126. ISSN 2474-9842

Crossfield, SSR orcid.org/0000-0001-7337-3527, Chaddock, NJM, Iles, MM orcid.org/0000-0002-2603-6509 et al. (2 more authors) (2022) Interplay between demographic, clinical and polygenic risk factors for severe COVID-19. International Journal of Epidemiology, 51 (5). pp. 1384-1395. ISSN 0300-5771

Castaneda-Garcia, C, Iyer, V, Nsengimana, J et al. (11 more authors) (2022) Defining novel causal SNPs and linked phenotypes at melanoma-associated loci. Human Molecular Genetics, 31 (17). pp. 2845-2856. ISSN 0964-6906

Liyanage, U, MacGregor, S, Bishop, DT orcid.org/0000-0002-8752-8785 et al. (24 more authors) (2022) Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma. The Journal of investigative dermatology, 142 (8). pp. 1607-1616. ISSN 0022-202X

Fuller, H, Moore, JB orcid.org/0000-0003-4750-1550, Iles, MM et al. (1 more author) (2022) Ethnic-specific associations between dietary consumption and gestational diabetes mellitus incidence: A meta-analysis. PLOS Global Public Health, 2 (5). e0000250. ISSN 2767-3375

Steinberg, J, Iles, MM orcid.org/0000-0002-2603-6509, Lee, JY et al. (11 more authors) (2022) Independent evaluation of melanoma polygenic risk scores in UK and Australian prospective cohorts. British Journal of Dermatology, 186 (5). pp. 823-834. ISSN 0007-0963

Taylor, JC orcid.org/0000-0002-2518-5799, Iversen, LH, Burke, D orcid.org/0000-0002-4342-7464 et al. (7 more authors) (2021) Influence of age on surgical treatment and postoperative outcomes of patients with colorectal cancer in Denmark and Yorkshire, England. Colorectal Disease, 23 (12). pp. 3152-3161. ISSN 1462-8910

Ong, J-S, Dixon-Suen, SC, Han, X et al. (21 more authors) (2021) A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization. Nature Communications, 12 (1). 246. ISSN 2041-1723

Simonin-Wilmer, I, Orozco-del-Pino, P, Bishop, DT orcid.org/0000-0002-8752-8785 et al. (2 more authors) (2021) An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations. Frontiers in Genetics, 12. 703901. ISSN 1664-8021

Potjer, TP, van der Grinten, TWJ, Lakeman, IMM et al. (8 more authors) (2021) Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma. Journal of Medical Genetics, 58 (11). pp. 760-766. ISSN 0022-2593

Cardinale, A, Cantalupo, S, Lasorsa, VA et al. (20 more authors) (2021) Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1. Human Molecular Genetics. ISSN 0964-6906

Zhang, T, Choi, J, Dilshat, R et al. (14 more authors) (2021) Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms. American Journal of Human Genetics (AJHG), 108 (9). pp. 1631-1646. ISSN 0002-9297

Xu, M, Mehl, L, Zhang, T et al. (25 more authors) (2021) A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR. American journal of human genetics, 108 (9). pp. 1611-1630. ISSN 0002-9297

Yang, F, Mortlock, S, MacGregor, S et al. (5 more authors) (2021) Genetic Relationship Between Endometriosis and Melanoma. Frontiers in Reproductive Health, 3. 711123. ISSN 2673-3153

Chen, H, Majumdar, A, Wang, L et al. (75 more authors) (2021) Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals. HGG advances, 2 (3). 100041. ISSN 2666-2477

Laskar, R, Ferreiro‐Iglesias, A, Bishop, DT et al. (11 more authors) (2020) Risk factors for melanoma by anatomical site: an evaluation of aetiological heterogeneity. British Journal of Dermatology. ISSN 0007-0963

Choi, J, Zhang, T, Vu, A et al. (24 more authors) (2020) Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature Communications, 11 (1). 2718. ISSN 2041-1723

Mangantig, E, MacGregor, S, Iles, MM orcid.org/0000-0002-2603-6509 et al. (17 more authors) (2020) Germline variants are associated with increased primary melanoma tumor thickness at diagnosis. Human Molecular Genetics, 29 (21). pp. 3578-3587. ISSN 0964-6906

Zulyniak, MA orcid.org/0000-0003-4944-5521, Fuller, H and Iles, MM orcid.org/0000-0002-2603-6509 (2020) Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis. Lifestyle Genomics. ISSN 2504-3161

Olsen, CM, Pandeya, N, Law, MH et al. (7 more authors) (2020) Does polygenic risk influence associations between sun exposure and melanoma?: a prospective cohort analysis. British Journal of Dermatology, 183 (2). pp. 303-310. ISSN 0007-0963

Dusingize, JC, Olsen, CM, An, J et al. (10 more authors) (2020) Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses. International Journal of Epidemiology, 49 (4). pp. 1236-1245. ISSN 0300-5771

Law, MH, Aoude, LG, Duffy, DL et al. (19 more authors) (2020) Multiplex melanoma families are enriched for polygenic risk. Human Molecular Genetics. ISSN 0964-6906

Zhang, YD, Hurson, AN, Zhang, H et al. (102 more authors) (2020) Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. Nature Communications, 11. 3353.

Landi, MT, Bishop, DT orcid.org/0000-0002-8752-8785, MacGregor, S et al. (158 more authors) (2020) Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nature Genetics, 52 (5). pp. 494-504. ISSN 1061-4036

Dube, U, Ibanez, L, Budde, JP et al. (9 more authors) (2020) Correction to: Overlapping genetic architecture between Parkinson disease and melanoma. Acta Neuropathologica, 139 (5). p. 963. ISSN 0001-6322

Avitabile, M, Succoio, M, Testori, A et al. (25 more authors) (2020) Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene. Carcinogenesis, 41 (3). pp. 284-295. ISSN 0143-3334

Dube, U, Ibanez, L, Budde, JP et al. (9 more authors) (2020) Overlapping genetic architecture between Parkinson disease and melanoma. Acta Neuropathologica, 139 (2). pp. 347-364. ISSN 0001-6322

Liyanage, UE, Law, MH, Melanoma Meta-analysis Consortium et al. (3 more authors) (2020) Is there a causal relationship between vitamin D and melanoma risk? : A Mendelian randomization study. British Journal of Dermatology, 182 (1). pp. 97-103. ISSN 0007-0963

Ntritsos, G, Dimou, N, Kypreou, K et al. (10 more authors) (2019) Assessment of melanoma candidate genes in a meta‐analysis of 16 534 melanoma cases. Journal of the European Academy of Dermatology and Venereology, 33 (10). e369-e370. ISSN 0926-9959

Duffy, DL, Zhu, G, Li, X et al. (42 more authors) (2019) Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nature Communications, 10. 299. ISSN 2041-1723

Cust, AE, Drummond, M, Kanetsky, PA et al. (18 more authors) (2018) Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies. Journal of Investigative Dermatology, 138 (12). pp. 2617-2624. ISSN 0022-202X

Duffy, DL, Zhu, G, Li, X et al. (42 more authors) (2018) Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. Nature Communications, 9. 4774. ISSN 2041-1723

Zhang, T, Choi, J, Kovacs, MA et al. (15 more authors) (2018) Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Research, 28 (11). pp. 1621-1635. ISSN 1088-9051

Liyanage, UE, Law, MH, Ong, JS et al. (7 more authors) (2018) Polyunsaturated fatty acids and risk of melanoma: A Mendelian randomisation analysis. International Journal of Cancer, 143 (3). pp. 508-514. ISSN 0020-7136

Visconti, A, Duffy, DL, Liu, F et al. (19 more authors) (2018) Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. Nature Communications, 9 (1). 1684. p. 1684. ISSN 2041-1723

Fang, J, Jia, J, Makowski, M et al. (38 more authors) (2018) Publisher correction: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nature Communications, 9. p. 16159.

Choi, J, Xu, M, Makowski, MM et al. (16 more authors) (2017) A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. Nature Genetics, 49 (9). pp. 1287-1413. ISSN 1061-4036

Fang, J, Jia, J, Makowski, M et al. (41 more authors) (2017) Functional characterisation of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nature Communications, 8. 15034. ISSN 2041-1723

Telomeres Mendelian Randomization Collaboration, Haycock, PC, Burgess, S et al. (196 more authors) (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncology, 3 (5). pp. 636-651. ISSN 2374-2437

Lubbe, SJ, Escott-Price, V, Brice, A et al. (16 more authors) (2016) Rare variants analysis of cutaneous malignant melanoma genes in Parkinson’s disease. Neurobiology of Aging, 48. 222.e1-222.e7. ISSN 0197-4580

Law, M, Bishop, DT orcid.org/0000-0002-8752-8785, Lee, JE et al. (78 more authors) (2015) Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nature Genetics, 47 (9). pp. 987-995. ISSN 1061-4036

Iles, MM, Bishop, DT, Barrett, JH et al. (1 more author) (2015) Response: The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length Response. JNCI: Journal of the National Cancer Institute, 107 (10). ARTN djv238. ISSN 0027-8874

Barrett, JH, Iles, MM, Dunning, AM et al. (1 more author) (2015) Telomere length and common disease: study design and analytical challenges. Human Genetics, 134 (7). pp. 679-689. ISSN 0340-6717

Freitag, DF, Butterworth, AS, Willeit, P et al. (150 more authors) (2015) Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes and Endocrinology, 3 (4). pp. 243-253. ISSN 2213-8587

Mitra, A, Conway, C, Walker, C et al. (17 more authors) (2010) Melanoma sentinel node biopsy and prediction models for relapse and overall survival. British Journal of Cancer, 103 (8). pp. 1229-1236. ISSN 0007-0920

Monograph

Choi, J, Zhang, T, Vu, A et al. (21 more authors) (2019) Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion. Working Paper. Cold Spring Harbor Laboratory (Submitted)

Conference or Workshop Item

Crossfield, SSR, Chaddock, NJM, Iles, MM orcid.org/0000-0002-2603-6509 et al. (2 more authors) (2022) Interplay between demographic, clinical and polygenic risk factors for severe COVID-19. In: 50th European Mathematical Genetics Meeting (EMGM) 2022, 21-22 Apr 2022, Cambridge, England.

Fuller, H, Moore, JB orcid.org/0000-0003-4750-1550, Iles, MM et al. (1 more author) (2021) Serum dietary-related metabolites are predictive of GDM risk in an ethnic specific manner: A multivariate analysis of the Born in Bradford cohort. In: The Nutrition Society Summer Conference 2021: Nutrition in a changing world, 06-08 Jul 2021, Online.

Lindstrom, S, Kar, S, Wang, L et al. (25 more authors) (2020) Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions. In: AACR Annual Meeting 2020, 27 Apr - 24 Jun 2020, Philadelphia, PA, USA.

Feng, H, Majumdar, A, Pasaniuc, B et al. (20 more authors) (2020) Cross-cancer cross-tissue Transcriptome-wide Association Study (TWAS) of 11 cancers identifies 56 novel genes. In: AACR Annual Meeting 2020, 27 Apr 2020, Philadelphia, PA, USA.

Liyanage, UE, Law, MH, Han, X et al. (8 more authors) (2019) Abstract 1592: Genome-wide meta-analysis of keratinocytic cancers identifies 26 novel risk loci. In: AACR Annual Meeting 2019, 29 Mar - 03 Apr 2019, Atlanta, GA, USA.

Proceedings Paper

Chatzigeorgiou, C, Mackie, SL, UKGCA Consortium et al. (4 more authors) (2018) Should cases with a clinical diagnosis of Giant Cell Arteritis be included in genetic association studies? Analysis of the UK Giant Cell Arteritis consortium cohort. In: Genetic Epidemiology. The 2018 Annual Meeting of the International Genetic Epidemiology Society, 14-16 Oct 2018, San Diego, Calif., USA. Wiley , pp. 691-692.

Bishop, DT, Iles, MM orcid.org/0000-0002-2603-6509, Newton-Bishop, JA et al. (16 more authors) (2018) Abstract 234: Understanding melanoma susceptibility through GWAS of risk phenotypes. In: Cancer Research. AACR Annual Meeting 2018, 14-18 Apr 2018, Chicago, Illinois. American Association for Cancer Research .

Mangantig, E, Iles, MM orcid.org/0000-0002-2603-6509, Newton-Bishop, JA et al. (2 more authors) (2017) Combining Genetic, Transcriptomic and Clinical Variables to Predict Melanoma-specific Survival. In: Genetic Epidemiology. The 2017 Annual Meeting of the International Genetic Epidemiology Society, 09-11 Sep 2017, Cambridge, UK. Wiley , p. 688.

Preprint

Olsen, CM, Pandeya, N, Law, MH et al. (6 more authors) (2019) Ultraviolet radiation exposure and melanoma: evidence for gene-environment interaction in a large prospective cohort. [Preprint]