Items where authors include "Ashcroft, AE"

Article

Cornwell, O, Ault, JR orcid.org/0000-0002-5131-438X, Bond, NJ et al. (2 more authors) (2021) An investigation of D76N β₂-microglobulin using protein footprinting and structural mass spectrometry. Journal of the American Society for Mass Spectrometry, 32 (7). pp. 1583-1592. ISSN 1044-0305

Groves, K, Ashcroft, AE, Cryar, A et al. (27 more authors) (2021) Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison. Analytical Chemistry. ISSN 0003-2700

Calabrese, AN, Schiffrin, B, Watson, M et al. (11 more authors) (2020) Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Nature Communications, 11. 2155. ISSN 2041-1723

Ebo, JS orcid.org/0000-0002-5684-4355, Saunders, JC, Devine, PWA et al. (12 more authors) (2020) An in vivo platform to select and evolve aggregation-resistant proteins. Nature Communications, 11. 1816. ISSN 2041-1723

Cornwell, O, Bond, NJ, Radford, SE orcid.org/0000-0002-3079-8039 et al. (1 more author) (2019) Long-Range Conformational Changes in Monoclonal Antibodies Revealed Using FPOP-LC-MS/MS. Analytical Chemistry, 91 (23). pp. 15163-15170. ISSN 0003-2700

Bunce, SJ, Wang, Y, Stewart, KL et al. (4 more authors) (2019) Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β₄₀ (Aβ₄₀) by the peptide fragment Aβ₁₆-₂₂. Science Advances, 5 (6). eaav8216. ISSN 2375-2548

Ashcroft, AE orcid.org/0000-0002-1676-123X (2019) Mass spectrometry-based studies of virus assembly. Current Opinion in Virology, 36. pp. 17-24. ISSN 1879-6257

Cornwell, O, Radford, SE orcid.org/0000-0001-9668-6366, Ashcroft, AE orcid.org/0000-0002-1676-123X et al. (1 more author) (2018) Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β₂-Microglobulin. Journal of The American Society for Mass Spectrometry, 29 (12). pp. 2413-2426. ISSN 1044-0305

Martin, EM, Jackson, MP, Gamerdinger, M et al. (6 more authors) (2018) Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins. Journal of Biological Chemistry, 293 (22). pp. 8554-8568. ISSN 0021-9258

Knight, PD, Karamanos, TK, Radford, SE orcid.org/0000-0002-3079-8039 et al. (1 more author) (2018) Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1. European Journal of Mass Spectrometry, 24 (1). pp. 129-140. ISSN 1469-0667

Schiffrin, R, Calabrese, AN, Higgins, AJ et al. (5 more authors) (2017) Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding. Journal of Molecular Biology, 429. pp. 3776-3792. ISSN 0022-2836

Devine, PWA, Fisher, HC, Calabrese, AN et al. (6 more authors) (2017) Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS. Journal of The American Society for Mass Spectrometry, 28 (9). pp. 1855-1862. ISSN 1044-0305

Calabrese, AN, Jackson, SM, Jones, LN et al. (10 more authors) (2017) Topological dissection of the membrane transport protein Mhp1 derived from cysteine accessibility and mass spectrometry. Analytical Chemistry, 89 (17). pp. 8844-8852. ISSN 0003-2700

Young, LM, Ashcroft, AE and Radford, SE orcid.org/0000-0002-3079-8039 (2017) Small molecule probes of protein aggregation. Current Opinion in Chemical Biology, 39. pp. 90-99. ISSN 1367-5931

Young, LM, Tu, LH, Raleigh, D et al. (2 more authors) (2017) Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers. Chemical Science, 8 (7). pp. 5030-5040. ISSN 2041-6520

Dobson, J, Kumar, A, Willis, LF orcid.org/0000-0001-6616-3716 et al. (8 more authors) (2017) Inducing protein aggregation by extensional flow. Proceedings of the National Academy of Sciences, 114 (18). pp. 4673-4678. ISSN 0027-8424

Phillips-Jones, MK, Channell, G, Kelsall, CJ et al. (7 more authors) (2017) Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin. Scientific Reports, 7. 46180. ISSN 2045-2322

Watkinson, TG, Calabrese, AN, Ault, JR orcid.org/0000-0002-5131-438X et al. (2 more authors) (2017) FPOP-LC-MS/MS Suggests Differences in Interaction Sites of Amphipols and Detergents with Outer Membrane Proteins. Journal of the American Society for Mass Spectrometry, 28 (1). pp. 50-55. ISSN 1044-0305

Kay, P, Hughes, SR, Ault, JR orcid.org/0000-0002-5131-438X et al. (2 more authors) (2017) Widespread, routine occurrence of pharmaceuticals in sewage effluent, combined sewer overflows and receiving waters. Environmental Pollution, 220 (Part B). pp. 1447-1455. ISSN 0269-7491

Dobson, CL, Devine, PWA, Phillips, JJ et al. (24 more authors) (2016) Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Scientific Reports, 6. 38644. ISSN 2045-2322

Iadanza, MG, Higgins, AJ, Schiffrin, R et al. (5 more authors) (2016) Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM. Nature Communications, 7. 12865.

Schiffrin, B, Calabrese, AN, Devine, PWA et al. (4 more authors) (2016) Skp is a multivalent chaperone of outer membrane proteins. Nature Structural and Molecular Biology, 23 (9). pp. 786-793. ISSN 1545-9993

Young, LM, Saunders, JC, Mahood, RA et al. (4 more authors) (2016) ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules. Methods, 95. pp. 62-69. ISSN 1046-2023

Saunders, JC, Young, LM, Mahood, RA et al. (7 more authors) (2016) An in vivo platform for identifying inhibitors of protein aggregation. Nature Chemical Biology, 12 (2). pp. 94-101. ISSN 1552-4450

Watkinson, TG, Calabrese, AN, Giusti, F et al. (3 more authors) (2015) Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry. International Journal of Mass Spectrometry, 391. pp. 54-61. ISSN 1387-3806

Calabrese, AN, Ault, JR, Radford, SE et al. (1 more author) (2015) Using hydroxyl radical footprinting to explore the free energy landscape of protein folding. Methods, 89. 38 - 44. ISSN 1046-2023

Rajabi, K, Reuther, J, Deuerling, E et al. (2 more authors) (2015) A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometry. Protein science : a publication of the Protein Society, 24 (8). 1282 - 1291. ISSN 0961-8368

Young, LM, Mahood, RA, Saunders, JC et al. (4 more authors) (2015) Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry. Analyst, 140. 6990 - 6999. ISSN 0003-2654

Holmes, K, Shepherd, DA, Ashcroft, AE et al. (3 more authors) (2015) Assembly pathway of hepatitis B core virus-like particles from genetically fused dimers. The Journal of Biological Chemistry, 290. 16238 - 16245.. ISSN 0021-9258

Scarff, CA, Almeida, B, Fraga, J et al. (3 more authors) (2015) Examination of ataxin-3 (atx-3) aggregation by structural mass spectrometry techniques: A rationale for expedited aggregation upon polyglutamine (polyQ) expansion. Molecular and Cellular Proteomics, 14 (5). 1241 - 1253. ISSN 1535-9476

Beeston, H, Ault, JR, Pringle, SD et al. (2 more authors) (2015) Changes in protein structure monitored by use of gas-phase hydrogen/deuterium exchange. Proteomics. ISSN 1615-9853

Tu, L-H, Young, L, Wong, AG et al. (3 more authors) (2015) Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions. Biochemistry, 54 (3). 666 - 676. ISSN 0006-2960

Calabrese, AN, Watkinson, TG, Henderson, PJF et al. (2 more authors) (2015) Amphipols outperform dodecylmaltoside micelles in stabilizing membrane protein structure in the gas phase. Analytical Chemistry, 87 (2). 1118 - 1126. ISSN 0003-2700

Young, LM, Saunders, JC, Mahood, RA et al. (6 more authors) (2015) Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry. Nature Chemistry, 7 (1). pp. 73-81. ISSN 1755-4330

Giusti, F, Rieger, J, Catoire, LJ et al. (7 more authors) (2014) Synthesis, characterization and applications of a perdeuterated amphipol. Journal of Membrane Biology, 247 (9-10). 909 - 924. ISSN 0022-2631

Shepherd, DA, Ariza, A, Edwards, TA et al. (3 more authors) (2014) Probing Bunyavirus N protein oligomerisation using mass spectrometry. Rapid Communications in Mass Spectrometry, 28 (7). 793 - 800. ISSN 0951-4198

Preston, GW, Radford, SE, Wilson, AJ et al. (1 more author) (2014) Analysis of amyloid nanostructures using photo-cross-linking: in situ comparison of three widely used photo-cross-linkers. ACS Chemical Biology, 9 (3). 761 - 768. ISSN 1554-8929

Leney, AC, Pashley, CL, Scarff, CA et al. (2 more authors) (2014) Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry. Molecular BioSystems, 10 (3). 412 - 420. ISSN 1742-206X

Eves-van den Akker, S, Lilley, CJ, Ault, JR et al. (3 more authors) (2014) The feeding tube of cyst nematodes: characterisation of protein exclusion. PLoS One, 9 (1). e87289. ISSN 1932-6203

Young, LM, Cao, P, Raleigh, DP et al. (2 more authors) (2013) Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors. Journal of the American Chemical Society, 136 (2). 660 - 670. ISSN 1520-5126

Shepherd, DA, Holmes, K, Rowlands, DJ et al. (2 more authors) (2013) Using ion mobility spectrometry-mass spectrometry to decipher the conformational and assembly characteristics of the hepatitis B capsid protein. Biophysical Journal, 105 (5). 1258 - 1267. ISSN 0006-3495

Alexander, CG, Juergens, MC, Shepherd, DA et al. (3 more authors) (2013) Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein. Proceedings of the National Academy of Sciences of USA, 110 (30). E2782 - E2791. ISSN 1091-6490

Ndlovu, H, Ashcroft, AE, Radford, SE et al. (1 more author) (2013) Molecular dynamics simulations of mechanical failure in polymorphic arrangements of amyloid fibrils containing structural defects. Beilstein Journal of Nanotechnology, 4. 429 - 440. ISSN 2190-4286

Ariza, A, Tanner, SJ, Walter, CT et al. (14 more authors) (2013) Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research, 41 (11). 5912 - 5926 (15). ISSN 0305-1048

Knapman, TW, Valette, NM, Warriner, SL et al. (1 more author) (2013) Ion mobility spectrometry-mass spectrometry of intrinsically unfolded proteins: trying to put order into disorder. Current Analytical Chemistry, 9 (2). 181 - 191. ISSN 1573-4110

Leney, AC, McMorran, LM, Radford, SE et al. (1 more author) (2012) Amphipathic polymers enable the study of functional membrane proteins in the gas phase. Analytical Chemistry, 84 (22). 9841 - 9847. ISSN 1086-4377

Phillips, HIA, Chernikov, AV, Fletcher, NC et al. (4 more authors) (2012) The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition. Chemistry - A European Journal, 18 (43). 13733 - 13742. ISSN 0947-6539

Hodkinson, JP, Radford, SE and Ashcroft, AE (2012) The role of conformational flexibility in β2-microglobulin amyloid fibril formation at neutral pH. Rapid Communications in Mass Spectrometry, 26 (16). 1783 - 1792. ISSN 0951-4198

Scarff, CA, Sicorello, A, Tomé, RJL et al. (3 more authors) (2012) A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3. International Journal of Mass Spectrometry, 345-34. 63 - 70. ISSN 1387-3806

Woods, LA, Platt, GW, Hellewell, AL et al. (4 more authors) (2011) Ligand binding to distinct states diverts aggregation of an amyloid-forming protein. Nature Chemical Biology, 7. 730 - 739. ISSN 1552-4469

Leney, AC, Phan, G, Allen, W et al. (4 more authors) (2011) Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of pilus biogenesis. Journal of the American Society for Mass Spectrometry, 22 (7). 1214 - 1223. ISSN 1044-0305

Book Section

Scarff, CA orcid.org/0000-0001-6168-0060, Ashcroft, AE orcid.org/0000-0002-1676-123X and Radford, SE orcid.org/0000-0002-3079-8039 (2016) Characterization of Amyloid Oligomers by Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry (ESI-IMS-MS). In: Eliezer, D, (ed.) Protein Amyloid Aggregation: methods and protocols. Methods in Molecular Biology, 1345 . Springer (Humana Press) , New York, N.Y., U.S.A. , pp. 115-132. ISBN 978-1-4939-2977-1