Burslem, G, Kyle, H, Breeze, AL orcid.org/0000-0001-9723-3350 et al. (4 more authors) (2016) Towards “Bionic” Proteins: Replacement of Continuous Sequences from HIF-1α with Proteomimetics to Create Functional p300 Binding HIF-1α Mimics. Chemical Communications, 52 (31). pp. 5421-5424. ISSN 1359-7345
Abstract
Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.