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Modeling Tissue Growth Within Nonwoven Scaffolds Pores

Edwards, S, Church, JS, Alexander, DLJ, Russell, SJ, Ingham, E, Ramshaw, JAM and Werkmeister, JA (2011) Modeling Tissue Growth Within Nonwoven Scaffolds Pores. Tissue Engineering. Part C. Methods, 17 (2). 123 - 130 . ISSN 1937-3384

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Abstract

In this study we present a novel approach for predicting tissue growth within the pores of fibrous tissue engineering scaffolds. Thin nonwoven polyethylene terephthalate scaffolds were prepared to characterize tissue growth within scaffold pores, by mouse NR6 fibroblast cells. On the basis of measurements of tissue lengths at fiber crossovers and along fiber segments, mathematical models were determined during the proliferative phase of cell growth. Tissue growth at fiber crossovers decreased with increasing interfiber angle, with exponential relationships determined on day 6 and 10 of culture. Analysis of tissue growth along fiber segments determined two growth profiles, one with enhanced growth as a result of increased tissue lengths near the fiber crossover, achieved in the latter stage of culture. Derived mathematical models were used in the development of a software program to visualize predicted tissue growth within a pore. This study identifies key pore parameters that contribute toward tissue growth, and suggests models for predicting this growth, based on fibroblast cells. Such models may be used in aiding scaffold design, for optimum pore infiltration during the tissue engineering process.

Item Type: Article
Academic Units: The University of Leeds > Faculty of Performance, Visual Arts and Communications (Leeds) > School of Design (Leeds)
The University of Leeds > Faculty of Biological Sciences (Leeds) > Institute of Molecular and Cellular Biology (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 12 Mar 2012 09:52
Last Modified: 08 Feb 2013 17:37
Published Version: http://dx.doi.org/10.1089/ten.tec.2010.0182
Status: Published
Publisher: Mary Anne Liebert Inc
Identification Number: 10.1089/ten.tec.2010.0182
URI: http://eprints.whiterose.ac.uk/id/eprint/43759

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