Mildred, Matthew, Chilcott, Jim and Hummel, Silvia (2011) A cost-effectiveness model of prostate cancer screening. In: YoungOR 17 Conference (YOR 17), 5 - 7 April 2011, Nottingham, UK.
Prostate cancer is the second most common cause of male cancer death in the UK, however due to the uncertainty around the health benefits and cost-effectiveness of a national screening programme, organised screening has not been adopted. A cost-effectiveness analysis was therefore conducted to examine the impact of a national prostate cancer screening programme on behalf of the UK National Screening Committee. A discrete event simulation model was developed to evaluate the use of the prostate specific antigen (PSA) blood test as a screening tool in the UK. The model comprises four parts: a disease natural history model which models the underlying disease itself; a calibration module which enables unobservable model parameters to be calibrated to observable data using a Metropolis-Hastings algorithm; a screening component which allows different screening options to be imposed on the population; and a resource impact model which calculates the resource implications of the alternative screening options. The model estimates incidence, lead time, over-detection, quality of life years (QALYs), mortality and resource implications of single and repeat screening strategies.
|Keywords:||Cost-effectiveness, discrete event simulation, calibration, prostate cancer, screening|
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
|Depositing User:||Mr Matthew Mildred|
|Date Deposited:||19 Apr 2011 15:29|
|Last Modified:||04 Jun 2014 18:55|