White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

A cost-effectiveness model of prostate cancer screening

Mildred, Matthew, Chilcott, Jim and Hummel, Silvia (2011) A cost-effectiveness model of prostate cancer screening. In: YoungOR 17 Conference (YOR 17), 5 - 7 April 2011, Nottingham, UK.


Download (605Kb)


Prostate cancer is the second most common cause of male cancer death in the UK, however due to the uncertainty around the health benefits and cost-effectiveness of a national screening programme, organised screening has not been adopted. A cost-effectiveness analysis was therefore conducted to examine the impact of a national prostate cancer screening programme on behalf of the UK National Screening Committee. A discrete event simulation model was developed to evaluate the use of the prostate specific antigen (PSA) blood test as a screening tool in the UK. The model comprises four parts: a disease natural history model which models the underlying disease itself; a calibration module which enables unobservable model parameters to be calibrated to observable data using a Metropolis-Hastings algorithm; a screening component which allows different screening options to be imposed on the population; and a resource impact model which calculates the resource implications of the alternative screening options. The model estimates incidence, lead time, over-detection, quality of life years (QALYs), mortality and resource implications of single and repeat screening strategies.

Item Type: Conference or Workshop Item (Lecture)
Keywords: Cost-effectiveness, discrete event simulation, calibration, prostate cancer, screening
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Depositing User: Mr Matthew Mildred
Date Deposited: 19 Apr 2011 15:29
Last Modified: 04 Jun 2014 18:55
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/42939

Actions (repository staff only: login required)