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A cost-effectiveness model of prostate cancer screening

Mildred, Matthew, Chilcott, Jim and Hummel, Silvia (2011) A cost-effectiveness model of prostate cancer screening. In: YoungOR 17 Conference (YOR 17), 5 - 7 April 2011, Nottingham, UK.

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Prostate cancer is the second most common cause of male cancer death in the UK, however due to the uncertainty around the health benefits and cost-effectiveness of a national screening programme, organised screening has not been adopted. A cost-effectiveness analysis was therefore conducted to examine the impact of a national prostate cancer screening programme on behalf of the UK National Screening Committee. A discrete event simulation model was developed to evaluate the use of the prostate specific antigen (PSA) blood test as a screening tool in the UK. The model comprises four parts: a disease natural history model which models the underlying disease itself; a calibration module which enables unobservable model parameters to be calibrated to observable data using a Metropolis-Hastings algorithm; a screening component which allows different screening options to be imposed on the population; and a resource impact model which calculates the resource implications of the alternative screening options. The model estimates incidence, lead time, over-detection, quality of life years (QALYs), mortality and resource implications of single and repeat screening strategies.

Item Type: Conference or Workshop Item (Lecture)
Keywords: Cost-effectiveness, discrete event simulation, calibration, prostate cancer, screening
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Depositing User: Mr Matthew Mildred
Date Deposited: 19 Apr 2011 15:29
Last Modified: 04 Jun 2014 18:55
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/42939

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