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Chemoinformatics Research at the University of Sheffield: A History and Citation Analysis

Bishop, N., Gillet, V.J., Holliday, J.D. and Willett, P. (2003) Chemoinformatics Research at the University of Sheffield: A History and Citation Analysis. Journal of Information Science, 29 (4). pp. 249-267. ISSN 0165-5515


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This paper reviews the work of the Chemoinformatics Research Group in the Department of Information Studies at the University of Sheffield, focusing particularly on the work carried out in the period 1985-2002. Four major research areas are discussed, these involving the development of methods for: substructure searching in databases of three-dimensional structures, including both rigid and flexible molecules; the representation and searching of the Markush structures that occur in chemical patents; similarity searching in databases of both two-dimensional and three-dimensional structures; and compound selection and the design of combinatorial libraries. An analysis of citations to 321 publications from the Group shows that it attracted a total of 3725 residual citations during the period 1980-2002. These citations appeared in 411 different journals, and involved 910 different citing organizations from 54 different countries, thus demonstrating the widespread impact of the Group's work.

Item Type: Article
Copyright, Publisher and Additional Information: © 2003 CILIP. This is an author produced electronic version of an article accepted for publication in Journal of Information Science. The definitive publisher authenticated version is available online at: http://jis.sagepub.com/cgi/reprint/29/4/249.
Keywords: Bibliometrics, Bioinformatics, Chemical database, Chemical patent, Chemical structure, Citation analysis, Cluster analysis, Combinatorial library design, Drug discovery, Genetic algorithms, Graph theory, Markush structure, Molecular diversity analysis, Pharmacophore searching, Similarity searching, Substructure searching
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Social Sciences (Sheffield) > Information School (Sheffield)
Depositing User: Repository Officer
Date Deposited: 15 Nov 2004
Last Modified: 04 Jun 2014 20:26
Published Version: http://jis.sagepub.com/cgi/reprint/29/4/249
Status: Published
Refereed: Yes
Identification Number: 10.1177/01655515030294003
URI: http://eprints.whiterose.ac.uk/id/eprint/173

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