Heck, T., Smeets, B., Vanmaercke, S. et al. (5 more authors) (2017) Modeling extracellular matrix viscoelasticity using smoothed particle hydrodynamics with improved boundary treatment. Computer Methods in Applied Mechanics and Engineering, 322. pp. 515-540. ISSN 0045-7825
Abstract
We propose viscoelastic smoothed particle hydrodynamics (SPH) with extended boundary conditions as a new method to model the extracellular matrix (ECM) in contact with a migrating cell. The contact mechanics between a cell and ECM is modeled based on an existing boundary method in SPH that corrects for the well-known missing kernel support problem in Fluid Structure Interactions (FSI). This boundary method is here extended to allow the modeling of moving boundaries in contact with a viscoelastic solid. To validate the method, simulations are performed of tractions applied to a viscoelastic solid, Stokes flow around an array of square pillars, and indentation of a viscoelastic material with a circular indenter. By drop out of the inertial terms in the SPH equations of motion, the new SPH formulation allows to solve problems in a low Reynolds environment with a timestep independent of the particle spacing, permitting to model processes at the cellular scale (i.e. -scale). The potential of the method to capture cell–ECM interactions is demonstrated by simulation of a self propelling object that locally degrades the ECM by fluidizing it to permit migration. This should enable us to model and understand realistic cell–matrix interactions in the future.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Computer Methods in Applied Mechanics and Engineering. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Smoothed particle hydrodynamics; Boundary conditions; Viscoelastic; Extracellular matrix; Degradation; Cell migration |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Mechanical Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Jun 2019 13:13 |
Last Modified: | 05 Jun 2019 15:19 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.cma.2017.04.031 |
Related URLs: |