Hurst, Timothy E. orcid.org/0000-0003-0524-2909, Gorman, Ryan, Drouhin, Pauline et al. (1 more author) (2018) Application of copper(II)-mediated radical cross-dehydrogenative coupling to prepare spirocyclic oxindoles and to a formal total synthesis of Satavaptan. Tetrahedron. pp. 6485-6496. ISSN 0040-4020
Abstract
Application of radical cross-dehydrogenative coupling (CDC) procedures to prepare a range of novel spirocyclic oxindoles and to a formal total synthesis of the vasopressin V2 receptor antagonist Satavaptan is reported. The key step involves a copper-mediated oxidative cyclisation of a simple linear anilide precursor to give the spirocyclic oxindole core. This synthetic approach was also used to prepare novel Satavaptan scaffolds and analogues.
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Copyright, Publisher and Additional Information: | © 2018 Elsevier Ltd. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. | ||||
Keywords: | Analogue synthesis, Copper, Cross-dehydrogenative coupling, Total synthesis, Vasopressin antagonists | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
Funding Information: |
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Depositing User: | Pure (York) | ||||
Date Deposited: | 22 Oct 2018 09:40 | ||||
Last Modified: | 06 Jan 2024 00:35 | ||||
Published Version: | https://doi.org/10.1016/j.tet.2018.09.026 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1016/j.tet.2018.09.026 | ||||
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Filename: Satavaptan_final_Aug_21_.docx
Description: Satavaptan - final Aug 21
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