Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Abstract

Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been explored as a therapeutic target. This review will focus on the evidence for mitochondrial abnormalities in the two most common neurodegenerative diseases, Parkinson's disease and Alzheimer's disease. In addition, we discuss the main strategies which have been explored in these diseases to target the mitochondria for therapeutic purposes, focusing on mitochondrially targeted antioxidants, peptides, modulators of mitochondrial dynamics and phenotypic screening outcomes.

Metadata

Item Type:	Article
Authors/Creators:	Macdonald, R. https://orcid.org/0000-0002-1344-3826 Barnes, K. Hastings, C. Mortiboys, H.
Copyright, Publisher and Additional Information:	© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. This is an author produced version of a paper subsequently published in Biochemical Society Transactions. Uploaded in accordance with the publisher's self-archiving policy.
Dates:	Published: 20 August 2018 Published (online): 19 July 2018
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Sheffield Teaching Hospitals
Depositing User:	Symplectic Sheffield
Date Deposited:	04 Sep 2018 10:52
Last Modified:	19 Jul 2019 00:43
Published Version:	https://doi.org/10.1042/BST20170501
Status:	Published
Publisher:	Portland Press
Refereed:	Yes
Identification Number:	10.1042/BST20170501
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:135269

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Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

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