Blair, N.F., Frith, T.R. and Barbaric, I. (2017) Genetic changes in human pluripotent stem cells: implications for basic biology and regenerative medicine. In: Human Gene Therapy. ESGCT XXV Anniversary Congress in Collaboration with the German Society for Gene Therapy, 17-20 Oct 2017, Berlin, Germany. Mary Ann Liebert , A8-A9.
Abstract
Chronic tissue and organ failure caused by an injury, disease, ageing or congenital defects represents some of the most complex therapeutic challenges and poses a significant financial healthcare burden. Regenerative medicine strategies aim to fulfil the unmet clinical need by restoring the normal tissue function either through stimulating the endogenous tissue repair or by using transplantation strategies to replace the missing or defective cells. Stem cells represent an essential pillar of regenerative medicine efforts as they provide a source of progenitors or differentiated cells for use in cell replacement therapies. Whilst significant leaps have been made in controlling the stem cell fates and differentiating them to cell types of interest, transitioning bespoke cellular products from an academic environment to off-the-shelf clinical treatments brings about a whole new set of challenges which encompass manufacturing, regulatory and funding issues. Notwithstanding the need to resolve such issues before cell replacement therapies can benefit global healthcare, mounting progress in the field has highlighted regenerative medicine as a realistic prospect for treating some of the previously incurable conditions.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Mary Ann Liebert. This is an author produced version of a paper subsequently published in Human Gene Therapy. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/L012537/1 MEDICAL RESEARCH COUNCIL MR/N009371/1 EUROPEAN COMMISSION - HORIZON 2020 668724 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Jul 2018 10:17 |
Last Modified: | 19 Dec 2022 13:49 |
Published Version: | https://doi.org/10.1089/hum.2017.29055.abstracts |
Status: | Published |
Publisher: | Mary Ann Liebert |
Refereed: | Yes |
Identification Number: | 10.1089/hum.2017.29055.abstracts |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:132684 |