Saeed, H., Jarman, P., Archer, S. et al. (7 more authors) (2017) Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie International Edition, 56 (41). pp. 12628-12633. ISSN 1433-7851
Abstract
Using a new mononuclear "building block," for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence "switch on" DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author produced version of a paper subsequently published in Angewandte Chemie International Edition. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | ruthenium(II); PDT; luminescence; ITC; singlet oxygen |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/M015572/1 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/P008070/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Aug 2017 08:45 |
Last Modified: | 24 Sep 2024 10:09 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201707350 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:120365 |