AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells

Webster, PJ, Littlejohns, AT, Gaunt, HJ et al. (3 more authors) (2017) AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells. Cell Cycle, 16 (22). pp. 2176-2182. ISSN 1538-4101

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2017 Peter John Webster, Anna Tiffany Littlejohns, Hannah Jane Gaunt, K. Raj Prasad, David John Beech, and Dermot Anthony Burke. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
Keywords: DNA damage; cell cycle; checkpoint kinase; colorectal cancer; mitosis
Dates:
  • Published: 9 November 2017
  • Accepted: 24 February 2017
  • Published (online): 15 March 2017
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Cardiovascular Medicine (Leeds)
The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds)
Funding Information:
FunderGrant number
British Heart FoundationFA/13/23/30122
British Heart FoundationFS/14/22/30734 - H Gaunt
MRCG1002076/1
Leeds Teaching Hospitals Charitable Foundation9R01/14-06
Depositing User: Symplectic Publications
Date Deposited: 03 Apr 2017 13:06
Last Modified: 29 Jan 2018 06:07
Published Version: https://doi.org/10.1080/15384101.2017.1301329
Status: Published
Publisher: Taylor & Francis
Identification Number: https://doi.org/10.1080/15384101.2017.1301329

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