Items where authors include "Melcher, A"

Article

Schuelke, MR, Gundelach, JH, Coffey, M et al. (7 more authors) (2022) Phase I trial of sargramostim/pelareorep therapy in pediatric patients with recurrent or refractory high-grade brain tumors. Neuro-Oncology Advances, 4 (1). pp. 1-10. ISSN 2632-2498

Appleton, E, Hassan, J, Chan Wah Hak, C et al. (7 more authors) (2021) Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade. Frontiers in Immunology, 12. 754436. ISSN 1664-3224

Kottke, T, Tonne, J, Evgin, L et al. (19 more authors) (2021) Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy. Nature Communications, 12 (1). 1930. ISSN 2041-1723

Müller, LME, Migneco, G, Scott, GB et al. (17 more authors) (2021) Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche. Journal for ImmunoTherapy of Cancer, 9 (3). e001803. ISSN 2051-1426

Andreou, T, Williams, J, Brownlie, R orcid.org/0000-0003-4897-1044 et al. (7 more authors) (2021) Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model. Journal for ImmunoTherapy of Cancer, 9 (3). e001143. ISSN 2051-1426

Challoner, BR, von Loga, K, Woolston, A et al. (13 more authors) (2020) Computational image analysis of T-cell infiltrates in resectable gastric cancer: association with survival and molecular subtypes. Journal of the National Cancer Institute. djaa051. ISSN 0027-8874

Driscoll, CB, Schuelke, MR, Kottke, T et al. (17 more authors) (2020) APOBEC3B-mediated Corruption of the Tumor Cell Immunopeptidome Induces Heteroclitic Neoepitopes for Cancer Immunotherapy. Nature Communications, 11. 790. ISSN 2041-1723

Huff, AL, Wongthida, P, Kottke, T et al. (12 more authors) (2018) APOBEC3 Mediates Resistance to Oncolytic Viral Therapy. Molecular Therapy - Oncolytics, 11. pp. 1-13.

Berkeley, RA, Steele, LP, Mulder, AA et al. (8 more authors) (2018) Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy. Cancer Immunology Research, 6 (10). pp. 1161-1173. ISSN 2326-6066

Annels, NE, Arif, M, Simpson, GR et al. (11 more authors) (2018) Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus. Molecular Therapy - Oncolytics, 9. C. pp. 1-12. ISSN 2372-7705

Samson, A orcid.org/0000-0002-3081-7850, Bentham, MJ orcid.org/0000-0003-2439-3198, Scott, K orcid.org/0000-0002-5790-9579 et al. (15 more authors) (2018) Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer. Gut, 67 (3). pp. 562-573. ISSN 0017-5749

Taggart, D, Andreou, T, Scott, KJ orcid.org/0000-0002-5790-9579 et al. (7 more authors) (2018) Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking. Proceedings of the National Academy of Sciences of the United States of America, 115 (7). E1540-E1549. ISSN 0027-8424

Kottke, T, Evgin, L, Shim, KG et al. (12 more authors) (2017) Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence. Cancer Immunology Research, 5 (11). pp. 1029-1045. ISSN 2326-6066

Cockle, JV, Brüning-Richardson, A orcid.org/0000-0002-9862-9805, Scott, KJ orcid.org/0000-0002-5790-9579 et al. (13 more authors) (2017) Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion. Molecular Therapy - Oncolytics, 5. pp. 75-86. ISSN 2372-7705

Ilett, E, Kottke, T, Thompson, J et al. (12 more authors) (2017) Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumor therapy. Gene Therapy, 24 (1). pp. 21-30. ISSN 0969-7128

Kottke, T, Shim, KG, Alonso-Camino, V et al. (12 more authors) (2016) Immunogenicity of self tumor associated proteins is enhanced through protein truncation. Molecular Therapy - Oncolytics, 3. 16030.

Holyoake, DL, Ward, E, Grose, D et al. (11 more authors) (2016) A phase-I trial of pre-operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the 'SPARC' trial protocol. BMC Cancer, 16. 728. ISSN 1471-2407

Cockle, JV, Rajani, K, Zaidi, S et al. (11 more authors) (2016) Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling. Neuro-Oncology, 18 (4). pp. 518-527. ISSN 1523-5866

Rajani, K, Parrish, C, Kottke, T et al. (10 more authors) (2016) Combination therapy with reovirus and anti-PD-1 blockade controls tumor growth through innate and adaptive immune responses. Molecular Therapy, 24 (1). pp. 166-174. ISSN 1525-0016

Turnbull, S, West, EJ, Scott, KJ et al. (3 more authors) (2015) Evidence for oncolytic virotherapy: Where have we got to and where are we going? Viruses, 7 (12). pp. 6291-6312. ISSN 1999-4915

Roulstone, V, Pedersen, M, Kyula, J et al. (14 more authors) (2015) BRAF- and MEK-targeted small molecule inhibitors exert enhanced antimelanoma effects in combination with oncolytic reovirus through ER stress. Molecular Therapy, 23 (5). pp. 931-942. ISSN 1525-0016

Cockle, JV, Picton, S, Levesley, J et al. (7 more authors) (2015) Cell migration in paediatric glioma; characterisation and potential therapeutic targeting. British Journal of Cancer, 112 (4). pp. 693-703. ISSN 0007-0920

Seth, R, Khan, AA, Pencavel, TD et al. (8 more authors) (2015) Adenovirally Delivered Enzyme Prodrug Therapy with Herpes Simplex Virus-Thymidine Kinase in Composite Tissue Free Flaps Shows Therapeutic Efficacy in Rat Models of Glioma. Plastic and Reconstructive Surgery, 135 (2). 475 - 487. ISSN 0032-1052

Zaidi, S, Blanchard, M, Shim, K et al. (13 more authors) (2015) Mutated BRAF emerges as a major effector of recurrence in a murine melanoma model after treatment with immunomodulatory agents. Molecular Therapy, 23 (5). 845 - 856. ISSN 1525-0016

Ilett, E orcid.org/0000-0002-9875-0322, Kottke, T, Donnelly, O et al. (10 more authors) (2014) Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus. Molecular Therapy, 22 (10). pp. 1851-1863. ISSN 1525-0016

Alonso-Camino, V, Rajani, K, Kottke, T et al. (12 more authors) (2014) The Profile of Tumor Antigens Which Can be Targeted by Immunotherapy Depends Upon the Tumor's Anatomical Site. Molecular Therapy, 22 (11). 1936 - 1948. ISSN 1525-0016

Bradley, S orcid.org/0000-0002-2038-2056, Jakes, A, Harrington, K et al. (3 more authors) (2014) Applications of coxsackievirus A21 in oncology. Oncolytic Virotherapy, 3. pp. 47-55. ISSN 2253-1572

Kottke, T, Boisgerault, N, Diaz, RM et al. (12 more authors) (2013) Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence. Nature Medicine, 19. 1625 - 1631. ISSN 1078-8956

Donnelly, O, Harrington, K, Melcher, A et al. (1 more author) (2013) Live viruses to treat cancer. Journal of the Royal Society of Medicine, 106 (8). 310 - 314. ISSN 0141-0768

Cockle, JV, Picton, SV and Melcher, A (2013) Future clinical potential of oncolytic virotherapy for pediatric CNS tumors. CNS Oncology, 2 (4). pp. 307-310. ISSN 2045-0907

Boisgerault, N, Kottke, T, Pulido, J et al. (11 more authors) (2013) Functional Cloning of Recurrence-specific Antigens Identifies Molecular Targets to Treat Tumor Relapse. Molecular Therapy, 21 (8). 1507 - 1516. ISSN 1525-0016

Donnelly, O, Vile, R, Pandha, H et al. (2 more authors) (2012) The hitchhiker's guide to virotherapy. Oncotarget, 3 (8). pp. 735-736. ISSN 1949-2553

Kottke, T, Errington, F orcid.org/0000-0003-2155-534X, Pulido, J et al. (12 more authors) (2011) Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. Nature Medicine, 17 (7). pp. 854-859. ISSN 1078-8956

Heinemann, L, Simpson, GR, Boxall, A et al. (8 more authors) (2011) Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer. BMC Cancer, 11 (1). ARTN 221. ISSN 1471-2407

Steele, L, Errington, F orcid.org/0000-0003-2155-534X, Prestwich, R et al. (7 more authors) (2011) Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming. Molecular Cancer, 10 (1). 20. ISSN 1476-4598

John, J, Ismail, M, Riley, C et al. (4 more authors) (2010) Differential effects of Paclitaxel on dendritic cell function. BMC Immunology, 11. 14. - . ISSN 1471-2172

Galivo, F, Diaz, RM, Wongthida, P et al. (5 more authors) (2010) Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma. Gene Therapy, 17 (2). pp. 158-170. ISSN 1476-5462

Craven, I, Crellin, A, Cooper, R et al. (3 more authors) (2007) Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer. British Journal of Cancer, 97 (10). pp. 1333-1337. ISSN 0007-0920

Merrick, AE, Errington, F orcid.org/0000-0003-2155-534X, Milward, K et al. (8 more authors) (2005) Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming. British Journal of Cancer, 92 (8). pp. 1450-1458. ISSN 0007-0920

Conference or Workshop Item

Anthoney, A, Samson, A orcid.org/0000-0002-3081-7850, West, E et al. (14 more authors) (2018) Single intravenous preoperative administration of the oncolytic virus Pexa-Vec to prime anti-tumor immunity. In: 2018 ASCO Annual Meeting, 01-05 Jun 2018, Chicago, Il, USA.

Proceedings Paper

Samson, A orcid.org/0000-0002-3081-7850, West, E, Turnbull, S et al. (13 more authors) (2019) 1213P: Single intravenous preoperative administration of the oncolytic virus Pexa-Vec to prime anti-tumor immunity. In: Abstract Book of the 44th ESMO Congress. European Society for Medical Oncology (ESMO) 2019 Congress, 27 Sep - 01 Oct 2019, Barcelona, Spain. Oxford University Press , v475-v532.

Turnbull, SJ, West, E, Scott, K et al. (3 more authors) (2018) Chemotherapy to reverse diminished immune responses (IRs) associated with a raised neutrophil lymphocyte ratio (NLR) in patients with advanced colorectal cancer (aCRC). In: Journal of Clinical Oncology. American Society of Clinical Oncology, 24 May 2018. American Society of Clinical Oncology .

Turnbull, S, West, E, Scott, K orcid.org/0000-0002-5790-9579 et al. (5 more authors) (2017) Revealing potential immune responses (IRs) in patients with advanced colorectal cancer (aCRC) on first line chemotherapy: A prospective study of neutrophil to lymphocyte ratio, immune function and outcome. In: Annals of Oncology. ESMO 2017 Congress, 08-12 Sep 2017, Madrid, Spain. Oxford University Press .

Samson, A orcid.org/0000-0002-3081-7850, Scott, K orcid.org/0000-0002-5790-9579, Taggart, D et al. (7 more authors) (2017) Intravenous delivery of oncolytic reovirus to brain tumours in patients to immunologically prime for sequential checkpoint blockade. In: Neuro-Oncology. 5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies (WFNOS), 04-07 May 2017, Zurich, Switzerland. Oxford University Press , iii53-iii53.

Schuelke, M, Evgin, L, Kottke, T et al. (8 more authors) (2016) Balancing Anti-Tumor Efficacy with Local Inflammatory Toxicity for the Treatment of Diffuse Intrinsic Pontine Glioma and Other Brain Tumors. In: Molecular Therapy. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 04-07 May 2016, Washington DC, USA. Nature Publishing Group , S77-S77.

Kottke, T, Rommelfanger, D, Shim, KG et al. (8 more authors) (2016) Escape from Tumor Dormancy Following Gene- or Viro-Therapies Is Mediated by Acquisition of a Phenotype in Which Innate Immune Surveillance Actively Drives Tumor Cell Recurrence. In: Molecular Therapy. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 04-07 May 2016, Washington DC, USA. Nature Publishing Group , S296-S296.

Kottke, T, Shim, KG, Evgin, L et al. (13 more authors) (2016) Immunogenicity of Self Tumor Associated Antigens Is Enhanced Through Protein Truncation. In: Molecular Therapy. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 04-07 May 2016, Washington DC, USA. Nature Publishing Group , S28-S28.

Khaled, YS, Wright, KE, Melcher, A et al. (1 more author) (2015) Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines. In: The Lancet. Spring Meeting for Clinician Scientists in Training 2015, 26 Feb 2015, Royal College of Physicians, London. Elsevier , S56 - S56.

Alonso-Camino, V, Rajani, K, Kottke, T et al. (11 more authors) (2014) The Profile of Tumor Antigens Which Can Be Targeted By Immunotherapy Depends Upon the Tumor's Anatomical Site. In: Molecular Therapy. 7th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT), 21-24 May 2014, Washington, DC, USA. Nature Publishing Group , S200-S200.

Cockle, J, Bruning-Richardson, A orcid.org/0000-0002-9862-9805, Picton, S et al. (5 more authors) (2013) PL-002. Cell Migration In Paediatric Glioma; Characterisation And Potential Therapeutic Targeting. In: NEURO-ONCOLOGY. 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO), 21-24 Nov 2013, San Francisco, CA. , p. 173.