Items where authors include "Ladbury, JE"

Article

Stainthorp, AK, Lin, C-C orcid.org/0000-0003-3071-172X, Wang, D et al. (6 more authors) (2023) Regulation of microRNA expression by the adaptor protein GRB2. Scientific Reports, 13. 9784. ISSN 2045-2322

Lingė, D, Gedgaudas, M, Merkys, A et al. (20 more authors) (2023) PLBD: protein–ligand binding database of thermodynamic and kinetic intrinsic parameters. Database, 2023. baad040. ISSN 1758-0463

Ladbury, JE orcid.org/0000-0002-6328-7200, Lin, C-C orcid.org/0000-0003-3071-172X and Suen, KM (2023) Phase separation enhances probability of receptor signalling and drug targeting. Trends in Biochemical Sciences, 48 (5). pp. 428-436. ISSN 0167-7640

Suen, KM, Sheard, TMD, Lin, C-C orcid.org/0000-0003-3071-172X et al. (3 more authors) (2023) Expansion microscopy reveals subdomains in C. elegans germ granules. Life Science Alliance, 6 (4). e202201650. ISSN 2575-1077

Seiler, C, Stainthorp, AK orcid.org/0000-0001-9561-0095, Ketchen, S et al. (4 more authors) (2022) The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation. Communications Biology, 5 (1). 1029. ISSN 2399-3642

Lin, C-C, Suen, KM, Jeffrey, P-A et al. (12 more authors) (2022) Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state. Molecular Cell. ISSN 1097-2765

Ketchen, SE, Gamboa-Esteves, FO, Lawler, SE et al. (7 more authors) (2022) Drug Resistance in Glioma Cells Induced by a Mesenchymal–Amoeboid Migratory Switch. Biomedicines, 10 (1). 9. ISSN 2227-9059

Rohwedder, A, Knipp, S, Roberts, LD orcid.org/0000-0002-1455-5248 et al. (1 more author) (2021) Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction. Scientific Reports, 11 (1). 6160. ISSN 2045-2322

Smirnovienė, J, Smirnov, A, Zakšauskas, A et al. (11 more authors) (2021) Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII. ChemistryOpen, 10 (5). pp. 567-580. ISSN 2191-1363

Lin, C-C orcid.org/0000-0003-3071-172X, Wieteska, L, Suen, KM et al. (3 more authors) (2021) Grb2 binding induces phosphorylation-independent activation of Shp2. Communications Biology, 4 (1). 437. ISSN 2399-3642

Suen, KM, Braukmann, F, Butler, R et al. (9 more authors) (2020) DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Nature Communications, 11. 4242. ISSN 2041-1723

Alshawli, AS, Wurdak, H, Wood, IC orcid.org/0000-0003-1886-2533 et al. (1 more author) (2020) Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes. Molecular Genetics & Genomic Medicine, 8 (10). e1429. ISSN 2324-9269

Ketchen, S, Rohwedder, A, Knipp, S et al. (7 more authors) (2020) A novel workflow for three-dimensional analysis of tumour cell migration. Interface Focus, 10 (2). 20190070. ISSN 2042-8898

Lin, C-C, Suen, KM, Stainthorp, A et al. (5 more authors) (2019) Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling. Cancer Letters, 457. pp. 86-97. ISSN 0304-3835

Fearnley, GW, Abdul-Zani, I, Latham, AM et al. (5 more authors) (2019) Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function. Biology Open, 8 (5). bio034215. ISSN 2046-6390

Maori, E, Navarro, IC, Boncristiani, H et al. (8 more authors) (2019) A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly. Molecular Cell, 74 (3). pp. 598-608. ISSN 1097-2765

Shahul Hameed, UF, Liao, C, Radhakrishnan, AK et al. (15 more authors) (2019) H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing. Nucleic Acids Research, 47 (5). pp. 2666-2680. ISSN 0305-1048

Linkuviene, V, Zubriene, A, Manakova, E et al. (7 more authors) (2018) Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design. Quarterly Reviews of Biophysics, 51. ARTN e10. pp. 1-48. ISSN 0033-5835

Honda, A, Kita, T, Seshadri, SV et al. (6 more authors) (2018) FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. Proceedings of the National Academy of Sciences of the United States of America, 115 (33). pp. 8388-8393. ISSN 0027-8424

Kinoshita, M, Lin, Y, Dai, I et al. (5 more authors) (2018) Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry. Chemical Communications, 54 (57). pp. 7995-7998. ISSN 1359-7345

Suen, KM, Lin, CC orcid.org/0000-0003-3071-172X, Seiler, C et al. (6 more authors) (2018) Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. International Journal of Biochemistry and Cell Biology, 94. pp. 89-97. ISSN 1357-2725

Kim, JY, Kinoshita, M, Kume, S et al. (9 more authors) (2016) Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity. Biochemical Journal, 473 (21). pp. 3837-3854. ISSN 0264-6021

Belousova, N, Mikheeva, G, Xiong, C et al. (9 more authors) (2016) Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget, 7 (33). pp. 53414-53429. ISSN 1949-2553

Timsah, Z, Ahmed, Z, Ivan, C et al. (17 more authors) (2016) Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene, 35 (17). pp. 2186-2196. ISSN 0950-9232

Timsah, Z, Berrout, J, Suraokar, M et al. (10 more authors) (2015) Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. American Journal of Cancer Research, 5 (10). 3135 - 3148. ISSN 2156-6976

Ahmed, Z, Timsah, Z, Suen, KM et al. (6 more authors) (2015) Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nature Communications, 6. 7534.

Bagheri-Yarmand, R, Sinha, KM, Gururaj, AE et al. (8 more authors) (2015) A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. Journal of Biological Chemistry, 290 (18). 11749 - 11761. ISSN 0021-9258

Poncet-Montange, G, Zhan, Y, Bardenhagen, JP et al. (11 more authors) (2015) Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2. Biochemical Journal, 466 (2). 337 - 346. ISSN 0264-6021

Dudutiene, V, Matuliene, J, Smirnov, A et al. (31 more authors) (2014) Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. Journal of Medicinal Chemistry, 57 (22). 9435 - 9446. ISSN 0022-2623

Aramini, JM, Hamilton, K, Ma, LC et al. (5 more authors) (2014) 19F NMR Reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus. Structure, 22 (4). 515 - 525. ISSN 0969-2126

Timsah, Z, Ahmed, Z, Lin, CC orcid.org/0000-0003-3071-172X et al. (8 more authors) (2014) Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion. Nature Structural and Molecular Biology, 21 (2). pp. 180-188. ISSN 1545-9993

Ladbury, JE, Hall, A and Skidmore, J (2014) The toolbox is open, but who should pay for the job? Nature Reviews Drug Discovery, 13 (7). 479 - 480. ISSN 1474-1776

Chan, CH, Morrow, JK, Li, CF et al. (11 more authors) (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell, 154 (3). 556 - 568. ISSN 0092-8674

Suen, KM, Lin, CC, George, R et al. (7 more authors) (2013) Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nature Structural and Molecular Biology, 20 (5). 620 - 627. ISSN 1545-9993

Ahmed, Z, Lin, C-C orcid.org/0000-0003-3071-172X, Suen, KM et al. (4 more authors) (2013) Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity. The Journal of Cell Biology, 200 (4). pp. 493-504. ISSN 0021-9525

Lin, CC orcid.org/0000-0003-3071-172X, Melo, FA, Ghosh, R et al. (6 more authors) (2012) Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2. Cell, 149 (7). pp. 1514-1524. ISSN 0092-8674

Keatch, SA, Leonard, PG, Ladbury, JE orcid.org/0000-0002-6328-7200 et al. (1 more author) (2005) StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI. Nucleic Acids Research, 33 (20). pp. 6540-6546. ISSN 0305-1048

Book Section

Paketurytė, V, Zubrienė, A, Ladbury, JE orcid.org/0000-0002-6328-7200 et al. (1 more author) (2019) Intrinsic Thermodynamics of Protein-Ligand Binding by Isothermal Titration Calorimetry as Aid to Drug Design. In: Ennifar, E, (ed.) Microcalorimetry of Biological Molecules: Methods and Protocols. Methods in Molecular Biology, 1964 . Springer (Humana Press) , New York, N.Y., U.S.A. , pp. 61-74. ISBN 978-1-4939-9178-5

Proceedings Paper

Ladbury, JE orcid.org/0000-0002-6328-7200 (2019) Receptor Tyrosine Kinase Signalling in the Absence of Kinase Activity and Cancer of Non-Genetic Origin. In: The Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S8-S8.

Morlacchia, P, Mandal, PK, Knight, JM et al. (4 more authors) (2013) Phosphopeptidomimetic Prodrugs Targeting STAT6 Inhibit Asthma Symptoms in a Mouse Model. In: Peptide Science. 23rd American Peptide Symposium, 22-27 Jun 2013, Waikoloa, Hawaii, USA. Wiley , p. 305.