Items where authors include "Grasby, J.A."

Article

Morton, S.B., Finger, L.D. orcid.org/0000-0002-2342-9569, van der Sluijs, R. et al. (9 more authors) (2023) Efficient synthesis of DNA duplexes containing reduced acetaldehyde interstrand cross-links. Journal of the American Chemical Society, 145 (2). pp. 953-959. ISSN 0002-7863

Algasaier, S.I., Finger, L.D. orcid.org/0000-0002-2342-9569, Bennet, I.A. et al. (1 more author) (2018) Flap endonuclease 1 mutations A159V and E160D cause genomic instability by slowing reaction on double-flap substrates. Biochemistry, 57 (50). pp. 6838-6847. ISSN 0006-2960

Thompson, M.J., Gotham, V., Ciani, B. orcid.org/0000-0001-7223-4154 et al. (1 more author) (2018) A conserved loop-wedge motif moderates reaction site search and recognition by FEN1. Nucleic Acids Research, 46 (15). pp. 7858-7872. ISSN 0305-1048

Bennet, I., Finger, L.D. orcid.org/0000-0002-2342-9569, Baxter, N.J. et al. (8 more authors) (2018) Regional Conformational Flexibility Couples Substrate Specificity and Scissile Phosphate Diester Selectivity in Human Flap Endonuclease 1. Nucleic Acids Research. gky293. ISSN 0305-1048

Tsutakawa, S.E., Thompson, M.J., Arvai, A.S. et al. (14 more authors) (2017) Phosphate steering by Flap Endonuclease 1 promotes 5´-flap specificity and incision to prevent genome instability. Nature Communications, 8 (1). 15855 . ISSN 2041-1723

Shaw, S.J., Finger, L.D. and Grasby, J.A. (2017) Human exonuclease 1 threads 5'-flap substrates through its helical arch. Biochemistry, 56 (29). pp. 3704-3707. ISSN 0006-2960

Algasaier, S.I., Exell, J.C., Bennet, I.A. et al. (6 more authors) (2016) DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1 Catalyzed Reaction. The Journal of Biological Chemistry, 291 (15). pp. 8258-8268. ISSN 0021-9258

Exell , J.C., Thompson , M.J., Finger, L.D. et al. (11 more authors) (2016) Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nature Chemical Biology, 12. pp. 815-821. ISSN 1552-4450

Kime, L., Clarke, J.E., Romero, D.A. et al. (2 more authors) (2014) Adjacent single-stranded regions mediate processing of tRNA precursors by RNase E direct entry. Nucleic Acids Research, 42 (7). pp. 4577-4589. ISSN 0305-1048

Patel, N., Atack, J.M., Finger, L.D. et al. (6 more authors) (2012) Flap endonucleases pass 5 '-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5 '-ends. Nucleic Acids Research, 40 (10). pp. 4507-4519. ISSN 0305-1048