Items where authors include "El-Khamisy, S.F."

Article

Rahmoon, M.A., Elghaish, R.A., Ibrahim, A.A. et al. (4 more authors) (2023) High glucose increases DNA damage and elevates the expression of multiple DDR genes. Genes, 14 (1). 144. ISSN 2073-4425

Elghzaly, A.A., Sun, C., Looger, L.L. et al. (34 more authors) (2022) Genome-wide association study for systemic lupus erythematosus in an egyptian population. Frontiers in Genetics, 13. 948505. ISSN 1664-8021

Ray, S., Abugable, A.A., Parker, J. et al. (8 more authors) (2022) A mechanism for oxidative damage repair at gene regulatory elements. Nature, 609 (7929). pp. 1038-1047. ISSN 0028-0836

Karyka, E., Berrueta Ramirez, N., Webster, C.P. orcid.org/0000-0003-4197-2036 et al. (11 more authors) (2022) SMN-deficient cells exhibit increased ribosomal DNA damage. Life Science Alliance, 5 (8). e202101145. ISSN 2575-1077

Lyon, R.F., Southam, H.M., Trevitt, C.R. et al. (4 more authors) (2022) CORM-3 induces DNA damage through Ru(II) binding to DNA. Biochemical Journal, 479 (13). pp. 1429-1439. ISSN 0264-6021

Fuchs, J., Schwer, B. and El-Khamisy, S.F. orcid.org/0000-0003-2721-7763 (2022) Editorial: Genomic instability and neurodegeneration. Frontiers in Aging Neuroscience, 14. 940459. ISSN 1663-4365

Palminha, N.M., Dos Santos Souza, C. orcid.org/0000-0001-5314-6263, Griffin, J. orcid.org/0000-0003-3969-7637 et al. (3 more authors) (2022) Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease. Cellular and Molecular Life Sciences, 79 (3). 160. ISSN 1420-682X

Elserafy, M,, El-Shiekh, I,, Fleifel, D, et al. (5 more authors) (2021) A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance. Life Science Alliance, 4 (10). e202000966. ISSN 2575-1077

Jurga, M., Abugable, A.A., Goldman, A.S.H. et al. (1 more author) (2021) USP11 controls R-loops by regulating senataxin proteostasis. Nature Communications, 12. 5156. ISSN 2041-1723

Kok, J.R., Palminha, N.M., Dos Santos Souza, C. orcid.org/0000-0001-5314-6263 et al. (2 more authors) (2021) DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity. Cellular and Molecular Life Sciences, 78 (15). pp. 5707-5729. ISSN 1420-682X

Ramachandran, S., Ma, T.S., Griffin, J. orcid.org/0000-0003-3969-7637 et al. (10 more authors) (2021) Hypoxia-induced SETX links replication stress with the unfolded protein response. Nature Communications, 12 (1). 3686.

Ashour, M.E., Allam, W., Elsayed, W. et al. (5 more authors) (2021) High temperature drives topoisomerase mediated chromosomal break repair pathway choice. Cancers, 13 (10). 2315. ISSN 2072-6694

Carmell, N., Rominiyi, O. orcid.org/0000-0002-9724-0224, Myers, K.N. et al. (9 more authors) (2021) Identification and validation of ERK5 as a DNA damage modulating drug target in glioblastoma. Cancers, 13 (5). 944. ISSN 2072-6694

Zaksauskaite, R., Thomas, R.C., van Eeden, F. et al. (1 more author) (2021) Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science Advances, 7 (5). eabc4165. ISSN 2375-2548

Halliwell, J.A., Frith, T.J.R., Laing, O. et al. (8 more authors) (2020) Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells. Stem Cell Reports, 14 (6). pp. 1009-1017. ISSN 2213-6711

Kim, H.R., Santhakumar, K., Markham, E. et al. (5 more authors) (2020) Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget, 11 (13). pp. 1109-1130. ISSN 1949-2553

Fielden, J., Wiseman, K., Torrecilla, I. et al. (14 more authors) (2020) TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts. Nature Communications, 11 (1). 1274. ISSN 2041-1723

Halliwell, J.A., Frith, T.J.R. orcid.org/0000-0002-6078-5466, Laing, O. et al. (8 more authors) (2019) Nucleosides rescue replication-mediated genome instability of human pluripotent stem cells. bioRxiv. (Submitted)

Fleifel, D., Rahmoon, M.A., AlOkda, A. et al. (3 more authors) (2018) Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s. Journal of Genetic Engineering and Biotechnology, 16 (2). pp. 427-432. ISSN 1687-157X

Shawky, S.M., Awad, A.M., Abugable, A.A. et al. (1 more author) (2018) Gold nanoparticles - an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. International Journal of Nanomedicine, 13. pp. 8137-8151. ISSN 1176-9114

Hegazy, M.T., Allam, W.R., Hussein, M.A. et al. (5 more authors) (2018) Increased genomic instability following treatment with direct acting anti-hepatitis C virus drugs. EBioMedicine, 35. pp. 106-113.

Elserafy, M., Abugable, A.A. orcid.org/0000-0003-1275-3328, Atteya, R. et al. (1 more author) (2018) Rad5, HLTF, and SHPRH: A fresh view of an old story. Trends in Genetics, 34 (8). pp. 574-577. ISSN 0168-9525

Mohamed, Z., Hassan, M.K., Okasha, S. et al. (7 more authors) (2018) miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2. Oncotarget, 9 (53). pp. 30053-30065.

Southam, H.M., Smith, T.W., Lyon, R.L. et al. (10 more authors) (2018) A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3. Redox Biology, 18. pp. 114-123.

Liao, C., Beveridge, R., Hudson, J.J.R. et al. (7 more authors) (2018) UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis. Cell Reports, 23 (11). pp. 3352-3365. ISSN 2211-1247

Walker, C. and El-Khamisy, S.F. orcid.org/0000-0003-2721-7763 (2018) Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia. Brain, 141 (5). pp. 1247-1262. ISSN 0006-8950

Walker, C., Herranz-Martin, S., Karyka, E. et al. (19 more authors) (2017) C9orf72 Expansion Disrupts ATM-mediated Chromosomal Break Repair. Nature Neuroscience, 20 (9). pp. 1225-1235. ISSN 1097-6256

Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Castelli, L.M., Ferraiuolo, L. et al. (23 more authors) (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. 16063 (2017).

Herranz-Martin, S., Chandran, J. orcid.org/0000-0002-3486-8583, Lewis, K. et al. (12 more authors) (2017) Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits. Disease Models and Mechanisms. ISSN 1754-8403

Chiang, S.C., Meagher, M. orcid.org/0000-0001-7552-9054, Kassouf, N. orcid.org/0000-0003-0519-1929 et al. (4 more authors) (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage. Science Advances, 3 (4). e1602506. ISSN 2375-2548

Meisenberg, C., Ashour, M.E., El-Shafie, L. et al. (7 more authors) (2017) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Research, 45 (3). pp. 1159-1176. ISSN 0305-1048

Atteya, R., Ashour, M.E., Ibrahim, E.E. et al. (2 more authors) (2017) Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. Mechanisms of Ageing and Development, 161 (A). pp. 141-148. ISSN 0047-6374

Elsayed, W., El-Shafie, L., Hassan, M.K. et al. (2 more authors) (2016) Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1. Scientific Reports, 6. 26626. ISSN 2045-2322

Mazouzi, A., Stukalov, A., Müller, A.C. et al. (13 more authors) (2016) A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 15 (4). pp. 893-908. ISSN 2211-1247

Hudson, J.J.R., Chiang, S.-C., Wells, O.S. et al. (2 more authors) (2012) SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair. Nature Communications, 3. 733. ISSN 2041-1723

El-Khamisy, S.F. orcid.org/0000-0003-2721-7763 (2011) To live or to die: a matter of processing damaged DNA termini in neurons. EMBO Molecular Medicine, 3 (2). pp. 78-88. ISSN 1757-4676