Wasilewski, J., Roleder, M., Niedziela, J. et al. (5 more authors) (2015) The role of septal perforators and "myocardial bridging effect" in atherosclerotic plaque distribution in the coronary artery disease. Polish Journal of Radiology, 80. pp. 195-201. ISSN 1733-134X
Abstract
The distribution of atherosclerotic plaque burden in the human coronary arteries is not uniform. Plaques are located mostly in the left anterior descending artery (LAD), then in the right coronary artery (RCA), circumflex branch (LCx) and the left main coronary artery (LM) in a decreasing order of frequency. In the LAD and LCx, plaques tend to cluster within the proximal segment, while in the RCA their distribution is more uniform. Several factors have been involved in this phenomenon, particularly flow patterns in the left and right coronary artery. Nevertheless, it does not explain the difference in lesion frequency between the LAD and the LCx as these are both parts of the left coronary artery. Branching points are considered to be the risk points of atherosclerosis. In the LCx, the number of side branches is lower than in the LAD or RCA and there are no septal perforators with intramuscular courses like in the proximal third of the LAD and the posterior descending artery (PDA). We hypothesized that septal branches generate disturbed flow in the LAD and PDA in a similar fashion to the myocardial bridge (myocardial bridging effect). This coronary architecture determines the non-uniform plaque distribution in coronary arteries and LAD predisposition to plaque formation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Pol J Radiol. This is an open access article published under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/), only allowing others to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. |
Keywords: | Atherosclerosis; Haemodynamics; Myocardial Bridge; Septal Branch |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Mechanical Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 Jun 2016 10:31 |
Last Modified: | 02 Jun 2016 10:37 |
Published Version: | http://dx.doi.org/10.12659/PJR.893227 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.12659/PJR.893227 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97730 |