Walmsley, S., Chilvers, E. and Whyte, M. (2009) Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Research & Therapy, 11. p. 219. ISSN 1478-6354
Full text not available from this repository.Abstract
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
| Item Type: | Article |
|---|---|
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield) |
| Depositing User: | Sheffield Import |
| Date Deposited: | 01 Oct 2009 11:11 |
| Last Modified: | 01 Oct 2009 11:11 |
| Published Version: | http://arthritis-research.com/content/11/2/219 |
| Status: | Published |
| Publisher: | Biomed Central |
| Identification Number: | 10.1186/ar2632 |
| URI: | http://eprints.whiterose.ac.uk/id/eprint/9759 |
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