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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

Walmsley, S., Chilvers, E. and Whyte, M. (2009) Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Research & Therapy, 11. p. 219. ISSN 1478-6354

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Abstract

With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 01 Oct 2009 11:11
Last Modified: 01 Oct 2009 11:11
Published Version: http://arthritis-research.com/content/11/2/219
Status: Published
Publisher: Biomed Central
Identification Number: 10.1186/ar2632
URI: http://eprints.whiterose.ac.uk/id/eprint/9759

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