Walmsley, S., Chilvers, E. and Whyte, M. (2009) Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Research & Therapy, 11. p. 219. ISSN 1478-6354
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield)|
|Depositing User:||Sheffield Import|
|Date Deposited:||01 Oct 2009 11:11|
|Last Modified:||01 Oct 2009 11:11|