White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

Walmsley, S., Chilvers, E. and Whyte, M. (2009) Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function. Arthritis Research & Therapy, 11. p. 219. ISSN 1478-6354

Full text not available from this repository.


With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies. Hypoxia inducible factor (HIF) was originally identified as a central transcriptional regulator of cellular responses to oxygen deprivation. However, the HIF signalling pathway now appears, in myeloid cells at least, to be a master regulator of both immune cell function and survival. As such, understanding the biology of HIF and its regulators may provide new approaches to myeloid-specific therapies that are urgently needed.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 01 Oct 2009 11:11
Last Modified: 01 Oct 2009 11:11
Published Version: http://arthritis-research.com/content/11/2/219
Status: Published
Publisher: Biomed Central
Identification Number: 10.1186/ar2632
URI: http://eprints.whiterose.ac.uk/id/eprint/9759

Actions (repository staff only: login required)