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A functional microsatellite in the macrophage migration inhibitory factor gene influences susceptibility to meningococcal sepsis

Renner, P., Roger, T., Faust, S., Schiesser, A., Knaup-Reymond, M., Betts, H., Bochud, P., Bochud, M., Read, R., Levin, M. and Calandra, T. (2007) A functional microsatellite in the macrophage migration inhibitory factor gene influences susceptibility to meningococcal sepsis. In: Sepsis 2007, 26–29 September 2007, Paris, France.

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Abstract

The cytokine migration inhibitory factor (MIF) has recently emerged as an important effector molecule of innate immune responses and sepsis. Two functional MIF promoter polymorphisms, a 5–8 CATT tetranucleotide repeat at -794 (CATT5–8) and a -173*G/C single nucleotide polymorphism, have been associated with susceptibility to and/or severity of rheumatoid arthritis, atopy and ulcerative colitis. Our objective was to study the impact of MIF gene polymorphisms on susceptibility to Neisseria meningitidis sepsis and to analyze the functional and biological effects of MIF polymorphisms in vitro.

Item Type: Conference or Workshop Item (Poster)
Copyright, Publisher and Additional Information: © 2007 BioMed Central Ltd
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
Depositing User: Sheffield Import
Date Deposited: 08 Oct 2009 15:08
Last Modified: 08 Oct 2009 15:08
Published Version: http://ccforum.com/content/11/S4/P35
Status: Published
URI: http://eprints.whiterose.ac.uk/id/eprint/9733

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