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Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid

Ottewell, P.D., Lefley, D.V., Coleman, R.E. and Holen, I. (2008) Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid. In: Breast Cancer Research 2008, 13 May 2008, London, UK.

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Abstract

Breast cancer patients commonly receive a combination of different therapies; for patients with late-stage breast cancer involving metastasis to the bone, a chemotherapeutic agent is usually given in combination with the antiresorptive drug zoledronic acid (zol) (Novartis Pharma, Basel, Switzerland). We have previously reported that administration of doxorubicin (dox) (Pharachemie BV, Haarlem, The Netherlands) 24 hours prior to zol inhibits subcutaneous breast tumour growth, inhibits tumour cell proliferation and increases apoptosis in vivo. The aims of the present study were to determine the mechanisms by which dox and zol exert their synergistic antitumour effects.

Item Type: Conference or Workshop Item (Poster)
Copyright, Publisher and Additional Information: © 2008 BioMed Central Ltd
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Division of Genomic Medicine (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 09 Oct 2009 10:12
Last Modified: 09 Oct 2009 10:12
Published Version: http://breast-cancer-research.com/content/10/S2/P8...
Status: Published
URI: http://eprints.whiterose.ac.uk/id/eprint/9721

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