Practical guide to sample size calculations: superiority trials

Abstract

A sample size justification is a vital part of any investigation. However, estimating the number of participants required to give meaningful results is not always straightforward. A number of components are required to facilitate a suitable sample size calculation. In this paper, the steps for conducting sample size calculations for superiority trials are summarised. Practical advice and examples are provided illustrating how to carry out the calculations by hand and using the app SampSize.

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Item Type:	Article
Authors/Creators:	Flight, L. https://orcid.org/0000-0002-9569-8290 Julious, S.A.
Copyright, Publisher and Additional Information:	© 2015 John Wiley & Sons, Ltd. This is an author produced version of a paper subsequently published in Pharmaceutical Statistics. Uploaded in accordance with the publisher's self-archiving policy.
Keywords:	sample size; superiority; power; clinical trials
Dates:	Published: 13 January 2016 Published (online): 20 November 2015 Accepted: 26 August 2015
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research
Depositing User:	Symplectic Sheffield
Date Deposited:	06 Apr 2016 15:15
Last Modified:	21 Nov 2016 23:02
Published Version:	http://dx.doi.org/10.1002/pst.1718
Status:	Published
Publisher:	Wiley
Refereed:	Yes
Identification Number:	10.1002/pst.1718
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:97114

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Practical guide to sample size calculations: superiority trials

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