Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Estrada, K., Styrkarsdottir, U., Evangelou, E. et al. (178 more authors) (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44 (5). pp. 491-501. ISSN 1061-4036

Abstract

Metadata

Authors/Creators:
  • Estrada, K.
  • Styrkarsdottir, U.
  • Evangelou, E.
  • Hsu, Y.H.
  • Duncan, E.L.
  • Ntzani, E.E.
  • Oei, L.
  • Albagha, O.M.
  • Amin, N.
  • Kemp, J.P.
  • Koller, D.L.
  • Li, G.
  • Liu, C.T.
  • Minster, R.L.
  • Moayyeri, A.
  • Vandenput, L.
  • Willner, D.
  • Xiao, S.M.
  • Yerges-Armstrong, L.M.
  • Zheng, H.F.
  • Alonso, N.
  • Eriksson, J.
  • Kammerer, C.M.
  • Kaptoge, S.K.
  • Leo, P.J.
  • Thorleifsson, G.
  • Wilson, S.G.
  • Wilson, J.F.
  • Aalto, V.
  • Alen, M.
  • Aragaki, A.K.
  • Aspelund, T.
  • Center, J.R.
  • Dailiana, Z.
  • Duggan, D.J.
  • Garcia, M.
  • Garcia-Giralt, N.
  • Giroux, S.
  • Hallmans, G.
  • Hocking, L.J.
  • Husted, L.B.
  • Jameson, K.A.
  • Khusainova, R.
  • Kim, G.S.
  • Kooperberg, C.
  • Koromila, T.
  • Kruk, M.
  • Laaksonen, M.
  • Lacroix, A.Z.
  • Lee, S.H.
  • Leung, P.C.
  • Lewis, J.R.
  • Masi, L.
  • Mencej-Bedrac, S.
  • Nguyen, T.V.
  • Nogues, X.
  • Patel, M.S.
  • Prezelj, J.
  • Rose, L.M.
  • Scollen, S.
  • Siggeirsdottir, K.
  • Smith, A.V.
  • Svensson, O.
  • Trompet, S.
  • Trummer, O.
  • van Schoor, N.M.
  • Woo, J.
  • Zhu, K.
  • Balcells, S.
  • Brandi, M.L.
  • Buckley, B.M.
  • Cheng, S.
  • Christiansen, C.
  • Cooper, C.
  • Dedoussis, G.
  • Ford, I.
  • Frost, M.
  • Goltzman, D.
  • González-Macías, J.
  • Kähönen, M.
  • Karlsson, M.
  • Khusnutdinova, E.
  • Koh, J.M.
  • Kollia, P.
  • Langdahl, B.L.
  • Leslie, W.D.
  • Lips, P.
  • Ljunggren, Ö.
  • Lorenc, R.S.
  • Marc, J.
  • Mellström, D.
  • Obermayer-Pietsch, B.
  • Olmos, J.M.
  • Pettersson-Kymmer, U.
  • Reid, D.M.
  • Riancho, J.A.
  • Ridker, P.M.
  • Rousseau, F.
  • Slagboom, P.E.
  • Tang, N.L.
  • Urreizti, R.
  • Van Hul, W.
  • Viikari, J.
  • Zarrabeitia, M.T.
  • Aulchenko, Y.S.
  • Castano-Betancourt, M.
  • Grundberg, E.
  • Herrera, L.
  • Ingvarsson, T.
  • Johannsdottir, H.
  • Kwan, T.
  • Li, R.
  • Luben, R.
  • Medina-Gómez, C.
  • Palsson, S.T.
  • Reppe, S.
  • Rotter, J.I.
  • Sigurdsson, G.
  • van Meurs, J.B.
  • Verlaan, D.
  • Williams, F.M.
  • Wood, A.R.
  • Zhou, Y.
  • Gautvik, K.M.
  • Pastinen, T.
  • Raychaudhuri, S.
  • Cauley, J.A.
  • Chasman, D.I.
  • Clark, G.R.
  • Cummings, S.R.
  • Danoy, P.
  • Dennison, E.M.
  • Eastell, R. https://orcid.org/0000-0002-0323-3366
  • Eisman, J.A.
  • Gudnason, V.
  • Hofman, A.
  • Jackson, R.D.
  • Jones, G.
  • Jukema, J.W.
  • Khaw, K.T.
  • Lehtimäki, T.
  • Liu, Y.
  • Lorentzon, M.
  • McCloskey, E.
  • Mitchell, B.D.
  • Nandakumar, K.
  • Nicholson, G.C.
  • Oostra, B.A.
  • Peacock, M.
  • Pols, H.A.
  • Prince, R.L.
  • Raitakari, O.
  • Reid, I.R.
  • Robbins, J.
  • Sambrook, P.N.
  • Sham, P.C.
  • Shuldiner, A.R.
  • Tylavsky, F.A.
  • van Duijn, C.M.
  • Wareham, N.J.
  • Cupples, L.A.
  • Econs, M.J.
  • Evans, D.M.
  • Harris, T.B.
  • Kung, A.W.
  • Psaty, B.M.
  • Reeve, J.
  • Spector, T.D.
  • Streeten, E.A.
  • Zillikens, M.C.
  • Thorsteinsdottir, U.
  • Ohlsson, C.
  • Karasik, D.
  • Richards, J.B.
  • Brown, M.A.
  • Stefansson, K.
  • Uitterlinden, A.G.
  • Ralston, S.H.
  • Ioannidis, J.P.
  • Kiel, D.P.
  • Rivadeneira, F.
Copyright, Publisher and Additional Information: © 2012 Macmillan Publishers Limited. This is an author produced version of a paper subsequently published in Nature Genetics. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Bone Density; Computational Biology; European Continental Ancestry Group; Extracellular Matrix Proteins; Female; Femur Neck; Fractures, Bone; Gene Expression Profiling; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Low Density Lipoprotein Receptor-Related Protein-5; Lumbar Vertebrae; Male; Mitochondrial Membrane Transport Proteins; Osteoporosis; Phosphoproteins; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Risk Factors; Spectrin
Dates:
  • Published: May 2012
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Depositing User: Symplectic Sheffield
Date Deposited: 19 Apr 2016 14:53
Last Modified: 29 Mar 2018 14:02
Published Version: http://dx.doi.org/10.1038/ng.2249
Status: Published
Publisher: Nature Publishing Group
Refereed: Yes
Identification Number: https://doi.org/10.1038/ng.2249
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