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Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2

Lewis, C.E. and Hughes, R. (2007) Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Research, 9 (3). p. 209. ISSN 1465-5411

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Abstract

Considerable evidence has now accumulated for tumour-associated macrophages stimulating key aspects of tumour progression, including the proliferation, survival and metastasis of tumour cells, tumour angiogenesis and suppression of the anti-tumour functions of other immune effectors at the tumour site. Tumour micro-environmental factors such as hypoxia have profound, direct effects on these cells, stimulating many of their pro-tumour functions. Hypoxia also does so indirectly by stimulating the release of the cytokine angiopoietin-2 from tumour cells and tumour blood vessels. This in turn then recruits Tie-2-expressing monocytes into tumours from the bloodstream and inhibits their production of anti-apoptotic and anti-angiogenic cytokines.

Item Type: Article
Copyright, Publisher and Additional Information: © 2007 BioMed Central Ltd
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
Depositing User: Sheffield Import
Date Deposited: 09 Oct 2009 08:51
Last Modified: 09 Oct 2009 08:51
Published Version: http://breast-cancer-research.com/content/9/3/209
Status: Published
Publisher: BioMed Central
Identification Number: 10.1186/bcr1679
URI: http://eprints.whiterose.ac.uk/id/eprint/9694

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