Walker, M.G., Jarman, P.J., Gill, M.R. et al. (9 more authors) (2016) A self-Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy. Chemistry - A European Journal, 22 (17). pp. 5996-6000. ISSN 0947-6539
Abstract
Although metal-ion-directed self-assembly has been widely used to construct a vast number of macrocycles and cages, it is only recently that the biological properties of these systems have begun to be explored. However, up until now, none of these studies have involved intrinsically photoexcitable self-assembled structures. Herein we report the first metallomacrocycle that functions as an intracellular singlet oxygen sensitizer. Not only does this Ru2Re2 system possess potent photocytotoxicity at light fluences below those used for current medically employed systems, it offers an entirely new paradigm for the construction of sensitizers for photodynamic therapy.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: | This paper has 12 authors. You can scroll the list below to see them all or them all.
|
Copyright, Publisher and Additional Information: | © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author produced version of a paper subsequently published in Chemistry - A European Journal. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 PIIF-GA-2008-219291 LEVERHULME TRUST (THE) RPG-2014-041 WELLCOME TRUST (THE) 097833/Z/11/Z ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) NONE |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 31 Mar 2016 14:43 |
Last Modified: | 14 Apr 2017 02:19 |
Published Version: | http://dx.doi.org/10.1002/chem.201600852 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201600852 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96862 |